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ANA Multiplex, Panel 1 with Reflexes *Build Your Own Panel Eligible [?]	$815	Compare Info
Description: This panel can be helpful in the diagnosis of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, mixed connective tissue disease, and rheumatoid arthritis. All specimens are screened for antinuclear antibodies (ANAs) with multiplex immunoassay. This approach simultaneously detects antibodies to dsDNA, chromatin, ribosomal protein, SSA, SSB, Smith (Sm), Sm/RNP, RNP, Scl-70, Jo-1, and centromere B. A positive result indicates the presence of at least 1 of these antibodies; a negative result indicates that none of the component antibodies were detected. Regardless of the result, this panel also detects antibodies to dsDNA, Sm, Sm/RNP, Scl-70, SSA and SSB as well as rheumatoid factor.ANA immunofluorescence assay (IFA) on HEp-2 cells is considered by the American College of Rheumatology as the current gold standard for ANA screening because of its overall high sensitivity for several autoimmune diseases [1]. However, because patients with other diseases and healthy individuals may be positive for ANA IFA, using immunoassays for screening may be more specific for a systemic rheumatic disorder [2]. On the other hand, multiplex immunoassay screening cannot rule out autoimmune diseases characterized by other antibodies, such as autoimmune hepatitis and primary biliary cholangitis, which may be positive for ANA IFA.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.⁠⁠⁠⁠⁠⁠⁠References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Fritzler MJ, et al. J Appl Lab Med. 2022;7:357-361. Categories: Price: $815
ANA Multiplex with Reflex to 11 Antibody Cascade *Build Your Own Panel Eligible [?]	$49	Compare Info
Description: This panel can be helpful in the diagnosis of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis, Sjogren syndrome, mixed connective tissue disease, and rheumatoid arthritis. All specimens are screened for antinuclear antibodies (ANAs) with multiplex immunoassay. This approach simultaneously detects antibodies to dsDNA, chromatin, ribosomal protein, SSA, SSB, Smith (Sm), Sm/RNP, RNP, Scl-70, Jo-1, and centromere B. A positive result indicates the presence of at least 1 of these antibodies; a negative result indicates that none of the component antibodies were detected.Specimens with positive results are subsequently tested for a series of disease-specific autoantibodies in cascade tiers. The first tier focuses on autoantibodies associated with systemic lupus erythematosus (SLE) and mixed connective tissue disease; the second tier detects autoantibodies seen in Sjogren Syndrome, progressive systemic sclerosis and polymyositis; and the third tier include markers of the limited form of systemic sclerosis and neuropsychiatric SLE. Note that the cascade stops with the first tier in which a positive antibody result is observed. Therefore, even if an antibody included in a subsequent tier is present, it will not be reported with this test.ANA immunofluorescence assay (IFA) on HEp-2 cells is considered by the American College of Rheumatology as the current gold standard for ANA screening because of its overall high sensitivity for several autoimmune diseases [1]. However, because patients with other diseases and healthy individuals may be positive for ANA IFA, using immunoassays for screening may be more specific for a systemic rheumatic disorder [2]. On the other hand, multiplex immunoassay screening cannot rule out patients with autoimmune diseases characterized by other antibodies, such as autoimmune hepatitis and primary biliary cholangitis, which may be positive for ANA IFA.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.⁠⁠⁠⁠⁠⁠⁠References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Fritzler MJ, et al. J Appl Lab Med. 2022;7:357-361. Categories: Price: $49
ANA Multiplex, with Reflex to dsDNA *Build Your Own Panel Eligible [?]	$49	Compare Info
Description: This multiplex immunoassay detects common antinuclear antibodies (ANAs) that are associated with autoimmune diseases. With a reflex to double-stranded DNA (dsDNA), this test may aid in the evaluation of systemic lupus erythematosus (SLE). Because of its limited sensitivity compared to that of ANA immunofluorescence-based tests, multiplex immunoassay is not the preferred assay for ANA testing [1].This multiplex immunoassay identifies antibodies to dsDNA, chromatin, ribosomal protein, SSA, SSB, Sm, Sm/RNP, RNP, Scl-70, Jo-1, and centromere B. A positive result indicates the presence of at least one of these autoantibodies. These autoantibodies have been associated with several autoimmune diseases, including SLE, systemic sclerosis, mixed connective tissue disease, polymyositis, and Sjogren syndrome. Antibodies to dsDNA are highly specific for SLE and may be detected before flares of the disease [2]. The 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria include antibodies to dsDNA in their immunology domains and criteria for SLE [3].A negative result of this test indicates none of the component autoantibodies were detected but does not rule out the autoimmune diseases characterized by other autoantibodies, such as autoimmune hepatitis and primary biliary cholangitis. The classic ANA immunofluorescence assay on human epithelial type 2 cells, an assay that can detect up to 150 antibodies, is considered by the ACR as the current gold standard for ANA testing [1].The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.⁠⁠⁠⁠⁠⁠⁠References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Tozzoli R, et al. Am J Clin Pathol. 2002;117(2):316-324.3. Aringer M, et al. Ann Rheum Dis. 2019;78(9):1151-1159. Categories: Price: $49
Anaplasma phagocytophilum and E.chaffeensis Antibody Panel Reflex to Titers *Build Your Own Panel Eligible [?]	$728	Compare Info
Description: This panel is for the detection of IgG and IgM antibodies against Anaplasma phagocytophilum and Ehrlichia chaffeensis. Anaplasmosis (human granulocytic anaplasmosis) and Ehrlichiosis (human monocytic ehrlichiosis) are tickborne diseases caused by transmission of the bacteria via the bite of an infected tick. Anaplasmosis is most common in the Northeastern and upper Midwestern United States. Ehrlichiosis is most common in the eastern, southeastern and south-central United States.Testing for tickborne disease is based on a clinical evaluation and risk of tick exposure with consideration to the geographic region. Symptoms may be nonspecific, including headache, fever/chills, malaise, myalgia, gastrointestinal symptoms, and rash. Infection can have similarities with other tickborne illnesses with overlapping vectors, geographic endemicity, and similar clinical signs and symptoms, including Borrelia burgdorferi (Lyme disease) and Babesia microti.Negative results can occur early in infection. Nucleic acid amplification tests are the preferred method for diagnosis during acute infection. Seroconversion or a four-fold increase between acute and convalescent sera can be used to support a diagnosis. The presence of IgG alone may indicate past infection, and IgM may persist for many months after infection has resolved. Antibody levels may remain elevated for several years after acute illness. Cross-reactivity between Anaplasma and Ehrlichia spp can occur. Therefore, interpretation of serologic results is done in the context of pertinent clinical picture, including timing from symptom onset.References: 1. Tickborne Diseases of the United States. A Reference Manual for Healthcare Providers, Sixth Edition, 2022. Centers for Disease Control and Prevention.2. Clinical Testing and Diagnosis for Anaplasmosis. Centers for Disease Control and Prevention. Last updated May 15, 2024. https://www.cdc.gov/anaplasmosis/hcp/diagnosis-testing/index.html3. Miller, MJ, et al. Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5:ciae104.doi: 10.1093/cid/ciae104.4. Biggs, HM, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. MMWR Recomm Rep. 2016 May 13;65(2):1-44.5. Clinical Testing and Diagnosis for Ehrlichiosis. Centers for Disease Control and Prevention. Last updated May 15, 2024. https://www.cdc.gov/ehrlichiosis/hcp/diagnosis-testing/index.html Categories: Price: $728
Anaplasma phagocytophilum Antibodies (IgG, IgM) with Reflex to Titers *Build Your Own Panel Eligible [?]	$443	Compare Info
Description: This test is for the detection of IgG and IgM antibodies against Anaplasma phagocytophilum to aid in the diagnosis of Anaplasmosis (human granulocytic anaplasmosis). Anaplasmosis is a tickborne disease caused by transmission of the bacteria via the bite of an infected tick. It is most common in the Northeastern and upper Midwestern United States during warmer months. Testing for Anaplasmosis is based on a clinical evaluation and risk of tick exposure with consideration to the geographic region. Symptoms may be nonspecific, including headache, fever/chills, malaise, myalgia, gastrointestinal symptoms, and rash (less common). Infection can have similarities with other tickborne illnesses with overlapping vectors, geographic endemicity, and similar clinical signs and symptoms, including Ehrlichia spp, Borrelia burgdorferi (Lyme disease) and Babesia microti. Negative results can occur early in infection. Nucleic acid amplification tests are the preferred method for diagnosis during acute infection. Seroconversion or a four-fold increase between acute and convalescent sera can be used to support a diagnosis. The presence of IgG alone may indicate past infection, and IgM may persist for many months after infection has resolved. Antibody levels may remain elevated for several years after acute illness. Cross-reactivity between related organisms Anaplasma and Ehrlichia spp, can occur. Therefore, interpretation of serologic results is done in the context of pertinent clinical picture, including timing from symptom onset. References:1. Tickborne Diseases of the United States. A Reference Manual for Healthcare Providers, Sixth Edition, 2022. Centers for Disease Control and Prevention.2. Clinical Testing and Diagnosis for Anaplasmosis. Centers for Disease Control and Prevention. Last updated May 15, 2024. https://www.cdc.gov/anaplasmosis/hcp/diagnosis-testing/index.html3. Miller, MJ, et al. Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5: ciae104.doi: 10.1093/cid/ciae104.4. Biggs, HM, et al. Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. MMWR Recomm Rep. 2016 May 13;65(2):1-44. Categories: Price: $443
Anaplasma phagocytophilum DNA, Qualitative Real-Time PCR *Build Your Own Panel Eligible [?]	$724	Compare Info
Description: Human granulocytic ehrlichiosis (HGE) DNA PCR is a highly sensitive and specific method to detect the agent responsible for HGE, Ehrlichia equi and Ehrlichia phagocytophilia. This assay does not recognize sequences for the human ehrlichial pathogen Ehrlichia chaffeensis. The diagnosis of HGE infection should be considered in conjunction with clinical presentation and additional established clinical tests. A negative PCR result indicates the absence of HGE at detectable levels in the sample tested and does not exclude the diagnosis of disease. Categories: Price: $724
Anaplastic Lymphoma Kinase 1 (ALK1), IHC with Interpretation *Build Your Own Panel Eligible [?]	$442	Compare Info
Description: The following CD markers are expressed on specific hematologic cells. Individual and a series of IHC markers can be run on unknown cells and presence or absence of the antigen can help to characterize the cell of interest. Categories: Price: $442
ANA Screen,IFA, with Reflex to Titer and Pattern/Mixed Connective Panel 2 *Build Your Own Panel Eligible [?]	$49	Compare Info
Description: This panel can be helpful in the diagnosis of individuals with clinical suspicion of mixed connective tissue disease (MCTD). All specimens are tested for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA) performed on human epithelial type 2 (HEp-2) cells. Specimens with positive ANA IFA results reflex to tests for ANA titer and pattern, RNP antibodies, double-stranded DNA (dsDNA) antibodies, and Scl-70 antibodies to aid in differential diagnosis.The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered by the American College of Rheumatology (ACR) as the current gold standard because of its overall high sensitivity for several autoimmune diseases [1]. Knowing the ANA titer and fluorescent staining pattern can be helpful in interpreting positive results [2]. The first indication of MCTD is often a high ANA titer (>1:1000), which occurs in 94% to 97% of patients with MCTD [3].Antibodies to RNP, dsDNA, and Scl-70 are included in this panel as reflex tests when the ANA IFA result is positive. The presence of RNP antibodies is considered the serologic hall mark of MCTD and is required to meet diagnostic criteria [3]. The presence of dsDNA and Scl-70 antibodies suggests systemic lupus erythematosus (SLE) and systemic sclerosis, respectively, but does not exclude MCTD [4]. Positive results on certain ANA tests may precede organ involvement (eg, presence of Scl-70 antibodies may precede esophageal involvement) or development of other autoimmune diseases (eg, presence of dsDNA antibodies may precede SLE) [3].Individuals with negative results on the ANA IFA usually also have negative results on specific autoantibodies. Therefore, subserology testing is not recommended for individuals without positive ANA IFA results and clinical suspicion of relevant autoimmune disease [5]. However, Jo-1 antibody may be detected in ANA IFA-negative patients with some types of myositis, and SSA antibody may be detected in some ANA IFA-negative patients with lupus or Sjogren syndrome [5].The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.⁠⁠⁠⁠⁠⁠⁠References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Tozzoli R, et al. Am J Clin Pathol. 2002;117(2):316-324.3. Cappelli S, et al. Semin Arthritis Rheum. 2012;41(4):589-598.4. Kavanaugh A, et al. Arch Pathol Lab Med. 2000;124(1):71-81.5. Yazdany J, et al. Arthritis Care Res (Hoboken). 2013;65(3):329-339. Categories: Price: $49
ANA Screen,IFA,with Reflex to Titer and Pattern/Rheumatoid Arthritis Panel1 *Build Your Own Panel Eligible [?]	$324	Compare Info
Description: This panel can be helpful in the diagnosis of autoimmune diseases with a focus on rheumatoid arthritis (RA) by simultaneously testing for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells, as well as the RA markers rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody (IgG). For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered by the American College of Rheumatology (ACR) as the current gold standard because of its overall high sensitivity for several autoimmune diseases [1]. Although RA is not generally associated with ANA, occasional patients may present with features of RA and SLE ("rhupus") and be positive for ANA and RA markers [2].This panel includes RF and CCP IgG antibody, 2 widely used laboratory markers that are included in the ACR/ European League Against Rheumatism classification (EULAR) criteria for RA [3]. The combination of RF and CCP antibody provides greater sensitivity than either assay alone [4] and is commonly used in the diagnostic evaluation of suspected RA.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Antonini L, et al. Autoimmun Rev. 2020;19(9):102612.3. Aletaha D, et al. Arthritis Rheum. 2010;62(9):2569-2581.4. Maksymowych WP, et al. J Rheumatol. 2014;41(11):2104-2113. Categories: Price: $324
ANA Screen,IFA, with Reflex to Titer and Pattern/Sjogren's Panel 2 *Build Your Own Panel Eligible [?]	$560	Compare Info
Description: This panel can be helpful in the diagnosis of Sjogren syndrome by simultaneously testing for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells, as well as SSA antibodies, SSB antibodies, rheumatoid factor (RF), thyroid peroxidase (TPO) antibodies, and anti-mitochondrial antibodies (AMAs). For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed. For specimens with positive AMA results, reflex testing for AMA titer is performed.The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered by the American College of Rheumatology (ACR) as the current gold standard because of its overall high sensitivity for several autoimmune diseases [1]. Knowing the ANA titer and fluorescent staining pattern can be helpful in interpreting positive results [2]. Individuals with negative results on the ANA IFA usually also have negative results on specific autoantibodies. However, SSA antibody may be detected in some ANA IFA-negative patients with lupus or Sjogren syndrome [3].The 2012 ACR classification criteria for Sjogren syndrome indicate that testing for SSA or SSB antibody has the highest sensitivity and specificity, and that a positive RF result in addition to an ANA titer ≥1:320 is consistent with Sjogren syndrome [4]. However, the 2016 ACR/European League Against Rheumatism (EULAR) classification criteria for Sjogren syndrome do not include SSB/La, RF, and ANA titer, because studies showed that these markers do not add sufficient value to SSA/Ro testing [5].Primary Sjogren syndrome is associated with an increased frequency of certain other autoimmune diseases [6]. Detecting characteristic markers, such as AMAs for primary biliary cholangitis and TPO antibodies for autoimmune thyroid disease, may aid in the evaluation of coexisting autoimmune diseases.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Tozzoli R, et al. Am J Clin Pathol. 2002;117(2):316-324.3. Yazdany J, et al. Arthritis Care Res (Hoboken). 2013;65(3):329-339.4. Shiboski SC, Arthritis Care Res (Hoboken). 2012;64(4):475-487.5. Shiboski CH, et al. Ann Rheum Dis. 2017;76(1):9-16.6. St. Clair EW, et al. Sjogren's Syndrome. In: Firestein GS, et al, eds. Kelley & Firestein's Textbook of Rheumatology. 10th ed. Elsevier; 2017. Categories: Price: $560
ANA Screen,IFA, with Reflex to Titer and Pattern/Systemic Sclerosis Panel 1 *Build Your Own Panel Eligible [?]	$338	Compare Info
Description: This panel may be used as part of an initial diagnostic evaluation of individuals with clinical suspicion of systemic sclerosis (SSc). This panel starts with an immunofluorescence assay (IFA) to detect antinuclear antibodies (ANAs). A positive result will reflex to 3 individual autoantibodies (antibodies to Scl-70, centromere B, and RNA polymerase III) that are associated with SSc.The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on human epithelial type 2 cells is considered by the American College of Rheumatology (ACR) as the current gold standard because of its overall high sensitivity for several autoimmune diseases [1]. ANAs can be detected in 90% to 95% of the patients with SSc; a negative ANA IFA result decreases the likelihood of SSc but does not exclude it. Knowing fluorescent staining patterns of an ANA IFA can be helpful in the differential diagnosis and guide selection of further testing for specific autoantibodies [2].Antibodies to centromere, Scl-70, and RNA polymerase III are included in this panel as reflex tests when the ANA IFA result is positive. The presence of any of these 3 autoantibodies is part of the ACR/European League Against Rheumatism (EULAR) classification criteria for SSc [3]. Identification of certain SSc-associated autoantibodies can help distinguish the various types of SSc and the organ(s) likely to be involved, which is important for determining prognosis and optimal treatment [2].Several other autoantibodies associated with SSc are less prevalent or less recently characterized and thus are not included in this panel (eg, antibodies to U1-snRNP, Th/To, and fibrillarin). Detecting these autoantibodies may also be helpful in the evaluation of SSc [2].The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Stochmal A, et al. Clin Rev Allergy Immunol. 2020;58(1):40-51.3. van den Hoogen F, et al. Arthritis Rheum. 2013;65(11):2737-2747. Categories: Price: $338
ANA Screen IFA w/ Ref to Titer and Pattern *Build Your Own Panel Eligible [?]	$85	Compare Info
Description: Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. Alternative Names(s): ANA A significant deviation from the normal range may require further evaluation by your physician. Includes: ANA Screen IFA w/ Ref to Titer and Pattern If ANA Screen, IFA is positive, ANA Titer and Pattern will be performed. Estimated turnaround for results is 4 business days. Patient Instructions: No fasting needed. Categories: Autoimmune diseases, Musculoskeletal diseases, Price: $85
ANCA Screen with MPO and PR3, with Reflex to ANCA Titer *Build Your Own Panel Eligible [?]	$411	Compare Info
Description: Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases, inflammatory bowel disease, as well as other autoimmune diseases. Categories: Price: $411
ANCA Screen with Reflex to ANCA Titer *Build Your Own Panel Eligible [?]	$253	Compare Info
Description: Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases (e.g., crescentic glomerulonephritis, microscopic polyarteritis and churg-strauss syndrome), bowel disease (Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis) as well as with other autoimmune diseases (drug-induced lupus, SLE, Felty's Syndrome). ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescent pattern observed. More recently the specific antigens responsible for these patterns have been described and isolated. The antigen that gives the C-ANCA pattern is Proteinase-3 (PR-3). Multiple antigens are responsible for P-ANCA pattern, the principle antigen being Myeloperoxidase (MPO). Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however may not be directed towards MPO. Patients with drug induced lupus, etc, often present with a P-ANCA pattern that is associated with antibodies against MPO. Categories: Price: $253
ANCA Vasculitides *Build Your Own Panel Eligible [?]	$388	Compare Info
Description: Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases (e.g., crescentic glomerulonephritis, microscopic polyarteritis and Churg-Strauss syndrome), bowel disease (Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis) as well as with other autoimmune diseases (drug-induced lupus, SLE, Felty's syndrome). ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescent pattern observed. More recently the specific antigens responsible for these patterns have been described and isolated. The antigen that gives the C-ANCA pattern is proteinase-3 (PR-3). Multiple antigens are responsible for P-ANCA pattern, the principle antigen being myeloperoxidase (MPO). Patients with vascular diseases will generally have either a C-ANCA pattern or P-ANCA pattern, and give positive results in specific tests for PR-3 or MPO. Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however, may not be directed towards MPO. Patients with drug induced lupus, etc., often present with a P-ANCA pattern that is associated with antibodies against MPO. Categories: Price: $388
Anchovy (f313) IgE *Build Your Own Panel Eligible [?]	$49	Compare Info
Description: This test detects the presence of specific IgE against anchovy. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148. Categories: Price: $49
Androgen Receptor, IHC with Interpretation *Build Your Own Panel Eligible [?]	$436	Compare Info
Description: Androgen receptor (AR) is expressed in 60-70% of breast cancers and is associated with favorable outcome among the ER+ subset. There is interest in AR as a target of hormonal therapy for breast carcinoma. Categories: Price: $436
Androgen Receptor, IHC without Interpretation *Build Your Own Panel Eligible [?]	$366	Compare Info
Description: Androgen receptor (AR) is expressed in 60-70% of breast cancers and is associated with favorable outcome among the ER+ subset. There is interest in AR as a target of hormonal therapy for breast carcinoma. Categories: Price: $366
Androstenedione *Build Your Own Panel Eligible [?]	$454	Compare Info
Description: Checks hormone levels in your blood. Measures androstenedione in your system. Monitors hormone balance for health. Includes: Androstenedione Categories: Price: $454
Androstenedione, Response to ACTH Stimulation *Build Your Own Panel Eligible [?]	$792	Compare Info
Description: Androstenedione may be useful in evaluating patients with androgen excess and managing patients with congenital adrenal hyperplasia (CAH), Categories: Price: $792
Anemia Profile (Advanced)	$129	Compare Info
Description: Anemia is a deficiency of red blood cells and/or hemoglobin. The most common type of anemia is iron deficiency anemia. The Anemia Profile measures the level of anemic-related blood chemistries. A significant deviation from the normal range may require further evaluation by your physician. Includes: Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils) Ferritin, Serum Folate (Folic Acid) Iron, Serum w/ TIBC: Total Iron, Iron Binding Capacity, % Saturation (calculated) Reticulocyte Count Vitamin B12 Patient Instructions: Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia. Some tests in this panel may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). Patient should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. Folate assays of samples from patients receiving therapy with certain pharmaceuticals (eg, methotrexate or leucovorin), are contraindicated because of the cross-reactivity of folate binding protein with these compounds. Categories: Blood and blood diseases, Fitness, nutrition, anti-aging, Price: $129
Anemia Profile (Advanced) with CMP	$138	Compare Info
Description: Anemia is a deficiency of red blood cells and/or hemoglobin. The most common type of anemia is iron deficiency anemia. The Anemia Profile measures the level of anemic-related blood chemistries. A significant deviation from the normal range may require further evaluation by your physician. Includes: Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils) Comprehensive Metabolic Profile ( includes eGFR ): Albumin, Albumin/Globulin Ratio (calculated), Alkaline Phosphatase, ALT, AST, BUN/Creatinine Ratio (calculated), Calcium, Carbon Dioxide, Chloride, Creatinine with GFR Estimated, Globulin (calculated), Glucose, Potassium, Sodium, Total Bilirubin, Total Protein, Urea Nitrogen Ferritin, Serum Folate (Folic Acid) Iron, Serum w/ TIBC: Total Iron, Iron Binding Capacity, % Saturation (calculated) Reticulocyte Count Vitamin B12 Patient Instructions: Patient should fast for 12 hours preceding collection of specimen. Specimens should be collected in the morning since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia. Some tests in this panel may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). Patient should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. Folate assays of samples from patients receiving therapy with certain pharmaceuticals (eg, methotrexate or leucovorin), are contraindicated because of the cross-reactivity of folate binding protein with these compounds. Some tests in this panel may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). Patient should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample. Categories: Blood and blood diseases, Fitness, nutrition, anti-aging, Price: $138
Anemia Profile (Basic)	$77	Compare Info
Description: Anemia is a deficiency of red blood cells and/or hemoglobin. The most common type of anemia is iron deficiency anemia. The Anemia Profile measures the level of anemic-related blood chemistries. A significant deviation from the normal range may require further evaluation by your physician. Includes: Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils) Iron, Serum w/ TIBC: Total Iron, Iron Binding Capacity, % Saturation (calculated) Reticulocyte count Patient Instructions: Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia. Categories: Blood and blood diseases, Fitness, nutrition, anti-aging, Price: $77
Angioedema Panel, Hereditary, Comprehensive *Build Your Own Panel Eligible [?]	$484	Compare Info
Description: This panel is designed to assist in the diagnosis of hereditary angioedema. Categories: Price: $484
Angiotensin-Converting Enzyme (ACE) *Build Your Own Panel Eligible [?]	$71	Compare Info
Description: This test is useful in evaluating patients presenting with sarcoidosis, Gaucher's disease and lymphoangiomyomatosis in that the enzyme is increased in these clinical settings. Significant deviations from the normal range may require further evaluation by your physician. Includes: Angiotensin-Converting Enzyme (ACE) Estimated turnaround for results is 7 business days. Categories: Infectious diseases, Price: $71
Angiotensin Converting Enzyme (ACE) Polymorphism (Insertion/Deletion) *Build Your Own Panel Eligible [?]	$335	Compare Info
Description: Assess your heart disease risk Screen genetic blood pressure factors Track athletic endurance and strength traits Categories: Price: $335
Angiotensin II *Build Your Own Panel Eligible [?]	$306	Compare Info
Description: Detection of Angiotensin II aids in the differential diagnosis of renal hypertension. Categories: Price: $306
Angiotensin II Type 1 Receptor (AGTR1) Gene 1166A→C Polymorphism *Build Your Own Panel Eligible [?]	$479	Compare Info
Description: The ATR1 receptor gene polymorphism is associated with increased risk for hypertension and cardiovascular risk. Substantial increase in the c allele frequency was observed among patients with severe hypertension, particularly among individuals carrying DD ACE genotype. Categories: Price: $479
Anion Gap Panel (Electrolyte Balance) *Build Your Own Panel Eligible [?]	$39	Compare Info
Description: This panel comprises a group of 4 tests that provide information on an individual's electrolytes, acid-base, and water balance. A calculated anion gap is included to help diagnose metabolic acidosis. The panel is usually ordered during hospital and emergency room admission to help diagnose a range of conditions as well as monitor certain conditions or treatments that affect electrolyte balance [1,2]. Symptoms and signs of electrolyte, acid-base, and water imbalance may include dehydration, edema, vomiting, weakness, confusion, and cardiac arrhythmias. Categories: Price: $39
Anise (f271) IgE *Build Your Own Panel Eligible [?]	$49	Compare Info
Description: This test detects the presence of specific IgE against anise. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148. Categories: Price: $49
Antibody Screen, RBC with Reflex to Identification, Titer, and Antigen Typing *Build Your Own Panel Eligible [?]	$252	Compare Info
Description: This test is used to detect significant RBC antibodies. Alternative names: RBC Antibody Screen Categories: General wellness, Specific blood tests for women, Price: $252
Anticonvulsant Panel 1 *Build Your Own Panel Eligible [?]	$288	Compare Info
Description: See individual tests. Categories: Price: $288
Anti-Cyclic Citrullinated Peptide 3 (Anti-CCP3) IgG *Build Your Own Panel Eligible [?]	$300	Compare Info
Description: Highly specific for rheumatoid arthritis Predicts joint damage and progression Used in early diagnosis of RA Categories: Price: $300
Anti-DGP IgA (Deamidated Gliadin Peptide IgA) *Build Your Own Panel Eligible [?]	$87	Compare Info
Description: Detects early gluten sensitivity More sensitive than anti-gliadin tests Monitors treatment response Categories: Price: $87
Anti-dsDNA (Double-Stranded) Antibiodies, EIA *Build Your Own Panel Eligible [?]	$95	Compare Info
Description: dsDNA Antibody is detected in patients with active systemic lupus erythematosus (SLE) and approximately 20% of patients with Mixed Connective Tissue Disease. Significant deviations from the normal range may require further evaluation by your physician. Includes: DNA (ds) Antibody Alternative Name(s): Native DNA, dsDNA, Double-Stranded DNA Antibody, Anti-DNA, (dsDNA) Categories: Autoimmune diseases, Musculoskeletal diseases, Price: $95
Antigen-induced Lymphocyte Proliferation Panel (Candida, Tetanus, TB PPD) *Build Your Own Panel Eligible [?]	$1855	Compare Info
Description: Measurement of human lymphocyte proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. Lymphocyte proliferation response to antigens, such as Candida, tetanus toxoid and tuberculin purified protein derivative (PPD), are evaluated as a function of memory in cell-mediated immunity. Categories: Price: $1855
Anti-Gliadin IgG *Build Your Own Panel Eligible [?]	$284	Compare Info
Description: Screen for gluten sensitivity May signal non-celiac gluten sensitivity Check your health Categories: Price: $284
Antimicrobial Combinations, Cystic Fibrosis Panel *Build Your Own Panel Eligible [?]	$1352	Compare Info
Description: The use of antimicrobial combinations for the treatment of infectious diseases has become more common due to several factors including: more severe infections, development of organism resistance, and infection with multiple organisms. Antimicrobial combinations may help to expand the spectrum of coverage, minimize drug toxicity, minimize development of resistance, and may lead to antimicrobial combination synergy. Categories: Price: $1352
Antimicrobial Combination Synergy, 2 Drugs *Build Your Own Panel Eligible [?]	$290	Compare Info
Description: Check drug combination treatment effectiveness Screen for resistant infection concerns Guide difficult infection treatment decisions Categories: Price: $290
Antimony, Blood *Build Your Own Panel Eligible [?]	$302	Compare Info
Description: Exposure monitoring/investigation. Categories: Price: $302
Antimony, Hair *Build Your Own Panel Eligible [?]	$794	Compare Info
Description: Exposure monitoring/investigation. Not for clinical diagnostic purposes. Categories: Price: $794
Antimony, Serum/Plasma *Build Your Own Panel Eligible [?]	$302	Compare Info
Description: Exposure monitoring. Categories: Price: $302
Antimony, Urine *Build Your Own Panel Eligible [?]	$302	Compare Info
Description: Exposure monitoring/Investigation. Categories: Price: $302
Anti-Mullerian Hormone (AMH), Female *Build Your Own Panel Eligible [?]	$235	Compare Info
Description: Anti-Mullerian Hormone (AMH), Female - AMH-MIS may be used in the investigation of ovarian reserve since AMH concentrations in adult women reflect the number of small antral and preantral follicles entering the growth phase of their life cycle. These follicles are proportional to the number of primordial follicles that still remain in the ovary, or the ovarian reserve. AMH decreases throughout a woman's reproductive life, which reflects the continuous decline of the oocyte/follicle pool with age and, accordingly, ovarian aging. Patient Instructions: Administration of STRENSIQ may interfere in certain assays and may falsely elevate values. For patients receiving STRENSIQ, consideration should be given to using alternate methods. Categories: Price: $235
Antiphospholipid Syndrome Diagnostic Panel *Build Your Own Panel Eligible [?]	$1195	Compare Info
Description: Checks blood for clotting disorders Detects autoimmune issues affecting blood Screens for abnormal blood antibodies Includes: Cardiolipin Antibodies (IgA, IgG, IgM) Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM) Lupus Anticoagulant Evaluation with Reflex (PTT-LA and dRVVT with Reflex Confirmations) Categories: Price: $1195
Anti-Streptolysin O Antibody (ASO) *Build Your Own Panel Eligible [?]	$113	Compare Info
Description: This test is a sensitive test for recent streptococcal infection. A rise in ASO begins about one week after infection and peaks two to four weeks later. ASO levels do not rise with cutaneous infections. In the absence of complications or reinfection, the ASO level will fall to preinfection levels within 6 to 12 months. Over 80% of patients with acute rheumatic fever and 95% of patients with acute glomerulonephritis due to streptococci have elevated levels of ASO. Categories: Price: $113
Antithrombin III Activity and Antigen *Build Your Own Panel Eligible [?]	$849	Compare Info
Description: Aids in characterization of Antithrombin deficiency (AT, previously referred to as Antithrombin III) which is associated with increased thrombotic risk. Type I deficiency is characterized by reduction in activity and antigen levels simultaneously. With type II deficiency, activity levels are lower in comparison to the antigen levels (dysfunctional protein). Acquired deficiency, more common than inherited defects, can occur due to: liver disease, nephrotic syndrome, heparin therapy, disseminated intravascular coagulation (DIC), sepsis, and L-asparaginase chemotherapy.Anticoagulant Interference: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect to decrease (UFH may decrease levels physiologically but no assay interference); Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase activity levels; Rivaroxaban, Apixaban, Edoxaban (Factor Xa Inhibitors): no effect. Categories: Price: $849
Antithrombin III Activity with Reflex to Antithrombin III Antigen *Build Your Own Panel Eligible [?]	$498	Compare Info
Description: Aids in characterization of Antithrombin deficiency (AT, previously referred to as Antithrombin III) which is associated with increased thrombotic risk. Type I deficiency is characterized by reduction in activity and antigen levels simultaneously. With type II deficiency, activity levels are lower in comparison to the antigen levels (dysfunctional protein). Acquired deficiency, more common than inherited defects, can occur due to: liver disease, nephrotic syndrome, heparin therapy, disseminated intra- vascular coagulation (DIC), sepsis, and L-asparaginase chemotherapy.Anticoagulant Interference: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect to decrease (UFH may decrease levels physiologically but no assay interference); Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase activity levels; Rivaroxaban, Apixaban, Edoxaban (Factor Xa Inhibitors): no effect. Categories: Price: $498
Antithrombin III Antigen *Build Your Own Panel Eligible [?]	$468	Compare Info
Description: This test measures the level of antithrombin III in your blood, which is a protein that helps prevent abnormal blood clots. Low levels can increase the risk of developing blood clots. Categories: Blood and blood diseases, Price: $468
Anti-tTG IgA (Tissue Transglutaminase IgA) *Build Your Own Panel Eligible [?]	$144	Compare Info
Description: Screen for celiac disease Monitor autoimmune response Assess gut inflammation Categories: Price: $144

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