Insulin Autoantibody
*Build Your Own Panel Eligible [?]
|
$413
|
|
|
Description:
Key clinical use and differentiatorsMeasurement of Insulin Autoantibody (IAA) is used to: 1. Screen for presymptomatic type 1 diabetes (T1D) in individuals with a family history of T1D or those known to have a high-risk HLA genotype, 2. Distinguish between T1D, type 2 diabetes mellitus (T2D), and atypical forms of diabetes such as latent autoimmune diabetes in adults (LADA). [1] Insulin Autoantibody (IAA) is used to help predict the need for insulin treatment in adults with diabetes who have not received treatment with insulin. [1]Intended Clinical UseThis test is crucial for differentiating between T1D and T2D. It is important to note that classifying diabetes type can be challenging at the time of presentation, and misdiagnosis can occur in approximately 40% of adults with new T1D. [1]Identifying individuals affected by stage 1 T1D is important for applying eligibility criteria to drugs, such as Teplizumab, which have demonstrated the ability to delay the transition of stage 1 to stage 3 T1D in clinical trials [2,3]IAA has some distinctive features, including that usually it is the first detected autoantibody in young children, [4] its appearance is more common in younger children [5] and its frequency of appearance declines with age. IAA is not informative for individuals treated with insulin, who often develop antibodies in response to injected insulin. [6]LimitationsT1D is classified into three stages, with stages 1 and 2 considered presymptomatic. Since the presence of stage 1 and 2 T1D requires at least two islet autoantibodies, relying solely on IAA as a screening test limits the ability to make an accurate diagnosis. Professional organizations, including the American Diabetes Association (ADA), recommend using tests for all four islet cell autoantibodies: IAA, glutamic acid decarboxylase (GAD65), Zinc Transporter 8 (ZnT8), and islet cell antigen 2 antibody (IA-2).[1]References1. American Diabetes Association Professional Practice C. 2. Diagnosis and Classification of Diabetes: Standards of care in Diabetes-2025. Diabetes Care. 2025;48:S27-S49. doi: 10.2337/dc25-S0022. Herold KC, Gitelman SE, Gottlieb PA, Knecht LA, Raymond R, Ramos EL. Teplizumab: A Disease-Modifying Therapy for Type 1 Diabetes That Preserves beta-Cell Function. Diabetes Care. 2023;46:1848-1856. doi: 10.2337/dc23-06753. Ramos EL, Dayan CM, Chatenoud L, Sumnik Z, Simmons KM, Szypowska A, Gitelman SE, Knecht LA, Niemoeller E, Tian W, et al. Teplizumab and beta-Cell Function in Newly Diagnosed Type 1 Diabetes. N Engl J Med. 2023;389:2151-2161. doi: 10.1056/NEJMoa23087434. Hummel S, Ziegler AG. Early determinants of type 1 diabetes: experience from the BABYDIAB and BABYDIET studies. Am J Clin Nutr. 2011;94:1821S-1823S. doi: 10.3945/ajcn.110. 0006465. Ziegler AG, Bonifacio E, Group B-BS. Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes. Diabetologia. 2012;55:1937-1943. doi: 10.1007/ s00125-012-2472-x6. Phillip M, Achenbach P, Addala A, Albanese-O'Neill A, Battelino T, Bell KJ, Besser REJ, Bonifacio E, Colhoun HM, Couper JJ, et al. Consensus Guidance for Monitoring Individuals With Islet Autoantibody-Positive Pre-Stage 3 Type 1 Diabetes. Diabetes Care. 2024. doi: 10.2337/ dci24-0042
Categories:
Price:
$413
|
|
Insulin, Fasting
*Build Your Own Panel Eligible [?]
|
$58
|
|
|
Description:
The lack of insulin causes the level of sugar in your blood to become abnormally high. When your body does not have enough insulin, it is hard for sugar to enter your cells. Sugar builds up in the blood. Too much sugar in your blood can cause many problems. These problems can be life-threatening if they are not treated. However, proper treatment can control your blood sugar level.
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Insulin.
Patient Instructions:
Fast for 12 hours prior to specimen collection. Fasting is defined as no consumption of food or beverage other than water for at least 12 hours before testing.
Categories:
Diabetes blood testing,
Price:
$58
|
|
Insulin, Free (Bioactive)
*Build Your Own Panel Eligible [?]
|
$374
|
|
|
Description:
The free insulin measurement is helpful in interpreting blood sugar concentration and its relationship to insulin injections in insulin-treated patients with insulin antibodies.
Patient Instructions:
Overnight fasting is required
Categories:
Price:
$374
|
|
Insulin, Human (c73) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test detects the presence of specific IgE against human insulin. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Insulin, Intact, LC/MS/MS
*Build Your Own Panel Eligible [?]
|
$218
|
|
|
Description:
Insulin is a key hormone involved in the control of blood glucose and regulation of fatty acid metabolism. Insulin measurement is primarily used to evaluate the cause of hypoglycemia. Inappropriately elevated insulin in blood (hyperinsulinemia) is associated with hypoglycemia(1) or in disorders linked to hyperglycemia, such as metabolic syndrome(2). Causes of hyperinsulinemia include insulinoma, insulin resistance, noninsulinoma pancreatogenous hypoglycemia syndrome, insulin antibodies, surreptitious insulin administration or other drug-induced hyperinsulinism (e.g., sulfonyl urea), incretin effects after bariatric surgery, and congenital hyperinsulinism. Insulin (test code 561) immunoassay can be used to evaluate the etiology of hypo- or hyperglycemia but is not equivalent to the LC/MS/MS test. Combined with LC/MS/MS measurement of C-peptide in the Cardio IQ Insulin Resistance Panel with Score (test code 36509), the assay can also help evaluate the likelihood that an individual has clinically significant insulin resistance or help in differential diagnosis (e.g., insulinoma versus exogenous insulin administration(3). The results of this test should be interpreted in the context of pertinent clinical history and physical examination findings.References1. Cryer PE, Axelrod L, Grossman AB, et al. Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2009;94(3):709-728. doi:10.1210/jc.2008-14102. Kelly CT, Mansoor J, Dohm GL, et al. Hyperinsulinemic syndrome: the metabolic syndrome is broader than you think. Surgery. 2014;156(2):405-411. doi:10.1016/j.surg.2014.04.0283. Abbasi F, Shiffman D, Tong CH, et al. Insulin resistance probability scores for apparently healthy individuals. J Endocr Soc. 2018;2(9):1050-1057. doi:10.1210/js.2018-00107
Categories:
Price:
$218
|
|
Insulin-Like Growth Factor I (IGF-I, LC/MS)
*Build Your Own Panel Eligible [?]
|
$95
|
|
|
Description:
IGF-1, also known as somatomedin-C, is a polypeptide hormone produced by the liver and other tissues in response to growth hormone release by the pituitary gland. IGF-1 effects growth promoting activity and glucose metabolism (insulin-like activity) in most human tissues. It is carried in blood bound to a carrier protein which prolongs its half-life; therefore making serum levels more constant than growth hormone while correlating with "average" circulating levels of growth hormone. In short, IGF-1 is a surrogate marker of growth hormone levels and activity.
Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
A significant deviation from the normal range may require further evaluation by your physician.
Alternative Name(s):
Somatomedin-C, Insulin-Like Growth Factor, IGF-1, SM-C/IGF-1
Includes:
Insulin-Like Growth Factor I (IGF-I).
Patient Instructions:
No fasting needed.
Categories:
Fitness, nutrition, anti-aging,
Hormones & metabolism,
Price:
$95
|
|
Insulin Response to Glucose, 2 Specimens
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
The insulin response to glucose infusion is useful in evaluating patients with hypoglycemia and suspected insulin-resistance.
Categories:
Price:
$49
|
|
Insulin Response to Glucose, 3 Specimens
*Build Your Own Panel Eligible [?]
|
$52
|
|
|
Description:
The insulin response to glucose infusion is useful in evaluating patients with hypoglycemia and suspected insulin-resistance.
Categories:
Price:
$52
|
|
Insulin Response to Glucose, 4 Specimens
*Build Your Own Panel Eligible [?]
|
$70
|
|
|
Description:
The insulin response to glucose infusion is useful in evaluating patients with hypoglycemia and suspected insulin-resistance.
Categories:
Price:
$70
|
|
Insulin Response to Glucose, 5 Specimens
*Build Your Own Panel Eligible [?]
|
$87
|
|
|
Description:
The insulin response to glucose infusion is useful in evaluating patients with hypoglycemia and suspected insulin-resistance.
Categories:
Price:
$87
|
|
Insulin Response to Glucose, 6 Specimens
*Build Your Own Panel Eligible [?]
|
$105
|
|
|
Description:
The insulin response to glucose infusion is useful in evaluating patients with hypoglycemia and suspected insulin-resistance.
Categories:
Price:
$105
|
|
Integrated Screen, Part 2
*Build Your Own Panel Eligible [?]
|
$1182
|
|
|
Description:
To assess maternal risk for carrying a fetus with Down Syndrome (Trisomy 21), Trisomy 18, or a neural tube defect. These types of tests are standard-of-care in obstetrics.
Categories:
Price:
$1182
|
|
Intensive Cardiovascular Panel Male & Female
|
$297
|
|
Description:
- Pinpoint the cause of heart issues
- Reveal hidden cholesterol problems
- Assess your risk for heart disease
Includes:
C-Reactive Protein (CRP), High Sensitivity (Cardiac Risk Assessment) Homocysteine, Cardiovascular Lipoprotein (a) Apolipoprotein A1, Apolipoprotein B, Apolipoprotein B/A1 Ratio (calculated) Vitamin D, 25-OH, Total; Vitamin D, 25-OH, D3; Vitamin D, 25-OH, D2 Fibrinogen Activity
Patient Instructions:
You should fast for 8-preferred hours before collection of the specimen. Fasting is defined as no consumption of food or beverage other than water for at least 8-preferred hours before testing. Estimated turnaround for results is 7 business days. If confirmation testing is required, the estimated time may be extended.
Categories:
Price:
$297
|
|
Interferon-alpha
*Build Your Own Panel Eligible [?]
|
$456
|
|
|
Description:
IFNalpha is mainly produced by monocytes/macrophages, lymphoblastic cells and fibroblasts, but different types of virus activated cells may produce the cytokine. IFNalpha shows antiviral, antiparasitic, and antiproliferative properties. Increased levels suggest recent or ongoing viral or parasitic infection.
Categories:
Price:
$456
|
|
Interleukin 17, Serum
*Build Your Own Panel Eligible [?]
|
$327
|
|
|
Description:
Primarily used for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.
Patient Instructions:
No biotin supplements 48 hours prior to blood draw
Categories:
Price:
$327
|
|
Interleukin-1 Beta
*Build Your Own Panel Eligible [?]
|
$794
|
|
|
Description:
IL-1 is a pro-inflammatory cytokine, and has also been associated with bone formation, insulin secretion, appetite regulation, fever reduction, neuronal development, and other conditions.
Alternative names: IL-1 Beta,CYTOKINE
Categories:
Allergy blood testing,
Infectious diseases,
Price:
$794
|
|
Interleukin-2 Receptor Alpha Chain (IL-2Ra/CD25), Soluble
*Build Your Own Panel Eligible [?]
|
$357
|
|
Description:
- Checks immune system activity levels.
- Measures body's inflammation response.
- Detects immune-related health conditions.
Patient Instructions:
No biotin supplements 48 hours prior to blood draw.
Categories:
Price:
$357
|
|
Interleukin-4 (IL-4), Serum
*Build Your Own Panel Eligible [?]
|
$374
|
|
|
Description:
Cytokines have emerged as molecules of importance in the regulation of many immunologic processes in the cell. The ability to accurately measure QN and QL differences in cytokine production is becoming increasingly important to the understanding of normal and pathological processes.
Categories:
Price:
$374
|
|
Interleukin-6 (IL-6), Serum
*Build Your Own Panel Eligible [?]
|
$501
|
|
Description:
- Measures body's inflammation response
- Checks for immune system activity
- Assesses body's infection indicators
Patient Instructions:
No biotin supplements 48 hours prior to blood draw
Categories:
Price:
$501
|
|
Interstitial Lung Disease Panel
*Build Your Own Panel Eligible [?]
|
$3586
|
|
|
Description:
A subset of interstitial lung disease (ILD) patients have underlying connective tissue diseases (CTDs). This panel serves as an aid for the diagnosis of CTDs, including rheumatoid arthritis, inflammatory myositis, systemic sclerosis, and Sjogrenโs syndrome, that are associated with the development of ILD. If left untreated, these CTD patients may develop lung fibrosis and inflammation. ILD is a direct consequence of these pathological changes. When severe, ILD leads to restrictive lung disease, pulmonary arterial hypertension, and cardiac disease (cor pulmonale).
Categories:
Price:
$3586
|
|
Intrinsic Factor Blocking Antibody
*Build Your Own Panel Eligible [?]
|
$308
|
|
|
Description:
Intrinsic factor is a protein that is produced by the parietal cells of the stomach. It binds to vitamin B12, thereby allowing absorption of the vitamin by intestinal cells. In pernicious anemia, an autoimmune disorder, autoantibodies are formed against intrinsic factor leading to its deficiency. The lack of intrinsic factor then causes malabsorption of vitamin B12 and subsequent anemia. Autoantibodies can also be formed directly against the parietal cells which similarly leads to inadequate intrinsic factor activity and vitamin B12 deficiency.
Patient Instructions:
Samples should not be collected from a patient who has received Vitamin B12 injection therapy within the last week.
Categories:
Price:
$308
|
|
Iodine, 24-Hour Urine
*Build Your Own Panel Eligible [?]
|
$246
|
|
|
Description:
Iodine is as essential element that is required for thyroid hormone production. The measurement of urinary iodine serves as an index of adequate intake.
Categories:
Allergy blood testing,
Geriatrics/Age Management,
Neurology,
Pediatrics,
Price:
$246
|
|
Iodine, Random Urine
*Build Your Own Panel Eligible [?]
|
$253
|
|
|
Description:
Iodine is an essential element that is required for thyroid hormone production. The measurement of urinary iodine serves as an index of adequate dietary intake.
Categories:
Price:
$253
|
|
Iodine, Serum/Plasma
*Build Your Own Panel Eligible [?]
|
$205
|
|
|
Description:
Iodine is an essential element that is required for thyroid hormone production. The measurement of iodine serves as an index of adequate dietary intake and iodine overload, particularly from iodine-containing drugs such as Amiodarone.
Patient Instructions:
No fasting needed.
Categories:
Allergy blood testing,
Geriatrics/Age Management,
Neurology,
Pediatrics,
Price:
$205
|
|
Iron, 24-Hour Urine
*Build Your Own Panel Eligible [?]
|
$158
|
|
Description:
- Check iron overload or deficiency risk
- Screen for unexplained fatigue causes
- Monitor iron levels over time
Categories:
Price:
$158
|
|
Iron, Comprehensive Panel
|
$76
|
|
|
Description:
This panel contains blood tests that will measure the amount of iron in your blood and measure your body's ability to use iron.
Significant deviations from the normal range may require further evaluation by your physician.
Includes:
Ferritin, Serum
Iron, Serum w/ TIBC: Total Iron, Iron Binding Capacity, % Saturation (calculated)
Patient Instructions:
Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia. In patients receiving therapy with high biotin doses (ie, > 5 mg/day), no sample should be taken until at least eight hours after the last biotin administration.
Categories:
Blood and blood diseases,
Fitness, nutrition, anti-aging,
General wellness,
Price:
$76
|
|
Iron Deficiency Anemia Profile
|
$85
|
|
|
Description:
Anemia is a blood disorder that is defined as: having fewer red blood cells than normal, or having less hemoglobin than normal (hemoglobin is the part of red blood cells that carries oxygen). When there are not enough red blood cells or there is too little hemoglobin, the blood is not able to carry enough oxygen to all parts of the body. Iron deficiency anemia is one of the most common forms of anemia.
Significant deviations from the normal range may require further evaluation by your physician.
Includes:
Complete Blood Count / CBC (includes Differential and Platelets): WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelet Count, MPV and Differential (Absolute and Percent - Neutrophils, Lymphocytes, Monocytes, Eosinophils, and Basophils)
Ferritin, Serum
Iron, Serum w/ TIBC: Total Iron, Iron Binding Capacity, % Saturation (calculated)
Reticulocyte count
Patient Instructions:
Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia. In patients receiving therapy with high biotin doses (ie, > 5 mg/day), no sample should be taken until at least eight hours after the last biotin administration.
Categories:
Blood and blood diseases,
Price:
$85
|
|
Iron, Liver Tissue
*Build Your Own Panel Eligible [?]
|
$585
|
|
|
Description:
Diagnosis of hemochromatosis using liver tissue specimens.
Categories:
Price:
$585
|
|
Iron, Serum
*Build Your Own Panel Eligible [?]
|
$53
|
|
|
Description:
The Serum Iron test can detect how much iron is in the blood. Serum measurements are useful in the diagnosis of iron deficiency and hemochromatosis.
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Iron, serum.
Patient Instructions:
Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia.
Categories:
Blood and blood diseases,
General wellness,
Fitness, nutrition, anti-aging,
Price:
$53
|
|
Iron, Serum w/ TIBC
*Build Your Own Panel Eligible [?]
|
$73
|
|
|
Description:
The Iron Test with Total iron-binding capacity (TIBC) can detect how much iron is in the blood. Serum iron quantification is useful in confirming the diagnosis of iron-deficiency anemia or hemochromatosis. The measurement of total iron binding in the same specimen may facilitate the clinician's ability to distinguish between low serum iron levels caused by iron deficiency from those related to inflammatory neoplastic disorders. The assay for iron measures the amount of iron which is bound to transferrin. The total iron binding capacity (TIBC) measures the amount of iron that would appear in blood if all the transferrin were saturated with iron. It is an indirect measurement of transferrin concentrations but expressed as an iron measurement. To obtain the percent saturation, the serum iron is divided by the TIBC which gives the actual amount of saturated transferrin. The percent saturation is low in iron deficiency and high in iron storage diseases.
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Total Iron,
Iron Binding Capacity,
% Saturation (calculated)
Patient Instructions:
Specimens should be collected in the morning from patients in a fasting state, since iron values decrease by 30% during the course of the day and there can be significant interference from lipemia.
Categories:
Blood and blood diseases,
General wellness,
Fitness, nutrition, anti-aging,
Price:
$73
|
|
Iron Storage Test (Ferritin)
*Build Your Own Panel Eligible [?]
|
$53
|
|
|
Description:
The Ferritin test measures the amount of iron stored by your body. This test can help diagnose excess iron levels as well as iron deficiency. Liver dysfunction and other factors can cause a reduction in the clearance of serum ferritin resulting in an increase in serum ferritin levels. Ferritin is an acute phase reactant that may be elevated in a wide-range of inflammatory conditions and infections.
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Ferritin, serum.
Patient Instructions:
No fasting needed. In patients receiving therapy with high biotin doses (ie, > 5 mg/day), no sample should be taken until at least eight hours after the last biotin administration.
Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.
Categories:
Blood and blood diseases,
Fitness, nutrition, anti-aging,
General wellness,
Price:
$53
|
|
Iron, TIBC and Ferritin Panel
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This serum iron study panel may help diagnose iron deficiency or overload. Because ferritin level can be affected by clinical conditions other than iron disorders, the measurement of transferrin saturation-calculated from serum iron level and total iron binding capacity (TIBC)-in the same serum specimen may facilitate the diagnosis of iron deficiency or overload [1-3].Serum ferritin level generally reflects body iron storage and can be used in the diagnosis of iron deficiency and overload. Transferrin saturation is the percentage of iron bound to transferrin. In patients with anemia, ferritin levels are most frequently used to determine whether iron deficiency is the cause [1]. However, as an acute phase protein, ferritin levels can be increased independently of iron status in inflammatory conditions, kidney disease, liver disease, and malignancy. In these clinical scenarios, the combination of ferritin level with other tests, such as transferrin saturation, may aid in the evaluation of iron deficiency [1,3].In patients with suspected hemochromatosis, transferrin saturation and serum ferritin may be included in the initial evaluation of iron overload [2]. The combination of a transferrin saturation under 45% and a normal serum ferritin level may help exclude iron overload. A transferrin saturation equal or over 45% alone or with an elevated ferritin level may suggest further testing. Serum ferritin level is also a predictor of advanced fibrosis [2].Note that reference intervals of serum iron, TIBC, transferrin saturation, and ferritin depend upon age and sex.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Ko CW, et al. Gastroenterology. 2020;159(3):1085-1094.2. Kowdley KV, et al. Am J Gastroenterol. 2019;114(8):1202-1218.3. Lopez A, et al. Lancet. 2016;387(10021):907-916.
Categories:
Price:
$49
|
|
Islet Cell Antibody Screen with Reflex to Titer
*Build Your Own Panel Eligible [?]
|
$297
|
|
|
Description:
Key clinical use and differentiatorsMeasurement of Islet cell antigen 2 antibodies(IA-2) is used to: 1. Screen for presymptomatic T1D in individuals with a family history of type 1 diabetes (T1D) or those known to have a high-risk HLA genotype, 2. Distinguish between T1D, type 2 diabetes mellitus (T2D), and atypical forms of diabetes such as latent autoimmune diabetes in adults (LADA). [1] Positivity to IA-2 represents a key marker of T1D. [1]Intended Clinical UseThis test is crucial for differentiating between T1D and T2D. It is important to note that classifying diabetes type can be challenging at the time of presentation, and misdiagnosis can occur in approximately 40% of adults with new T1D. [1]Identifying individuals affected by stage 1 T1D is important for applying eligibility criteria to drugs, such as Teplizumab, which have demonstrated the ability to delay the transition of stage 1 to stage 3 T1D in clinical trials. [2,3]IA-2 has some distinctive features. Its presence is associated with more-advanced islet autoimmunity and faster progression to stage 3 T1D. [4]LimitationsT1D is classified into three stages, with stages 1 and 2 considered presymptomatic. Since the presence of stage 1 and 2 T1D requires at least two islet autoantibodies, relying solely on IA-2 as a screening test limits the ability to make an accurate diagnosis. Professional organizations, including the American Diabetes Association (ADA), recommend using tests for all four islet cell autoantibodies: IAA, glutamic acid decarboxylase (GAD65), Zinc Transporter 8 (ZnT8), and islet cell antigen 2 antibody (IA-2). [1]References1. American Diabetes Association Professional Practice C. 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2025. Diabetes Care. 2025;48:S27-S49. doi: 10.2337/dc25-S0022. Herold KC, Gitelman SE, Gottlieb PA, Knecht LA, Raymond R, Ramos EL. Teplizumab: A Disease-Modifying Therapy for Type 1 Diabetes That Preserves beta-Cell Function. Diabetes Care. 2023;46:1848-1856. doi: 10.2337/dc23-06753. Ramos EL, Dayan CM, Chatenoud L, Sumnik Z, Simmons KM, Szypowska A, Gitelman SE, Knecht LA, Niemoeller E, Tian W, et al. Teplizumab and beta-Cell Function in Newly Diagnosed Type 1 Diabetes. N Engl J Med. 2023;389:2151-2161. doi: 10.1056/NEJMoa23087434. Decochez K, De Leeuw IH, Keymeulen B, Mathieu C, Rottiers R, Weets I, Vandemeulebroucke E, Truyen I, Kaufman L, Schuit FC, et al. IA-2 autoantibodies predict impending type 1 diabetes in siblings of patients. Diabetologia. 2002;45: 1658-1666. doi: 10.1007/s00125-002-0949-8
Categories:
Price:
$297
|
|
Isocitrate Dehydrogenase 1 and 2 (IDH1/IDH2) Mutation Analysis
*Build Your Own Panel Eligible [?]
|
$1028
|
|
|
Description:
IDH1 and IDH2 (Isocitrate dehydrogenase 1 and 2) encode enzymes that catalyzes oxidative decarboxylation of isocitrate into alpha-ketoglutarate (alpha-KG). Gain-of-function mutations in the IDH genes are associated with aberrant conversion of alpha-KG to 2-hydroxyglutarate (2-HG), which is an oncogenic metabolite, and are recurrent in myeloid malignancies and glioma. IDH1 (7-14%) exon 4 and IDH2 exon 4 (8-19%) mutations occur frequently in AML and are found to be associated with unfavorable prognosis and inferior overall survival in some studies. IDH inhibitors have been FDA-approved for IDH-mutated relapsed or refractory acute myeloid leukemia (AML).
Categories:
Price:
$1028
|
|
Isocyanate HDI (k77) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test detects the presence of specific IgE against hexamethylene diisocyanate (HDI). A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1]. More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.html Reference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Isocyanate MDI (k76) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test detects the presence of specific IgE against methylene diphenyl isocyanate (MDI). A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1]. More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.html Reference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Isocyanate TDI (k75) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test detects the presence of specific IgE against toluene diisocyanate (TDI). A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Isoniazid, Level
*Build Your Own Panel Eligible [?]
|
$386
|
|
Description:
- Check tuberculosis medication blood levels now
- Monitor dosing safety during treatment
- Screen for medication buildup risks
Categories:
Price:
$386
|
|
IsoPSAยฎ
*Build Your Own Panel Eligible [?]
|
$1527
|
|
|
Description:
IsoPSA is a structure-based (rather than concentration- based) assay that interrogates the entire spectrum of structural changes to PSA (or isoforms), and can effectively differentiate between high-grade prostate cancer and lowgrade prostate cancer/benign.
Categories:
Price:
$1527
|
|
Ispaghula (Psyllium) (k72) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test detects the presence of specific IgE against ispaghula. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Italian Cypress (t23) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test quantifies an individualโs IgE response to Italian cypress. This in vitro quantitative assay is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare professional after all clinical and laboratory findings have been evaluated. More specific information about this allergen can be found at http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/Tree-Pollens/Allergens/ItalianMediterraneanFuneral-cypress-/ Reference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(suppl 3):S1-S148.
Categories:
Price:
$49
|
|
Itraconazole
*Build Your Own Panel Eligible [?]
|
$501
|
|
|
Description:
The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted
Categories:
Price:
$501
|
|
Jack Mackerel/Scad (f60) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test is an allergen-specific IgE antibody test that quantifies an individualโs IgE response to jack Mackerel/scad. It is an in vitro quantitative assay, which is intended to be used in conjunction with other clinical information to aid in the diagnosis of food allergy [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. Food-specific IgE tests are extremely sensitive. However, a positive test result only indicates that a patient is IgE sensitized to the food of concern. Many IgE-sensitized patients do not develop any symptoms when this food is ingested. A diagnosis of food allergy should only be made by a trained medical provider, after conducting a thorough clinical evaluation [2,3]. While food-specific IgE test results may contribute to that evaluation, they cannot replace it. In this regard, detection of food-specific IgE in serum provides evidence of IgE sensitization, but a history of clinical reactivity to the food of concern, is required to make a diagnosis of IgE-mediated food allergy. Moreover, several forms of food hypersensitivity are not associated with the presence of food-specific IgE in serum. More specific information about this allergen can be found at http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/Food-of-Animal-Origin/Fish/Jack-mackerelScad/ References 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(suppl 3):S1-S148. 2. Sampson HA, et al. J Allergy Clin Immunol. 2014;134:1016-1025. 3. Boyce JA, et al. J Allergy Clin Immunol. 2010;126(6 suppl):S1-S58.
Categories:
Price:
$49
|
|
JAK2, Exon 12 Mutation Analysis
*Build Your Own Panel Eligible [?]
|
$757
|
|
Description:
- Checks for specific gene mutations
- Helps diagnose blood disorders
- Identifies JAK2 gene changes
Includes:
JAK2, Exon 12 Mutation Analysis
Categories:
Price:
$757
|
|
JAK2 V617F Mutation Analysis
*Build Your Own Panel Eligible [?]
|
$910
|
|
|
Description:
This DNA-based assay tests leukocytes from blood or bone marrow aspirate for mutation at codon 617 of JAK2, using an advanced DNA sequencing method. The JAK2 V617F mutation is associated with myeloproliferative neoplasms, including polycythemia vera, essential thrombocythemia and primary myelofibrosis.
Categories:
Price:
$910
|
|
JAK2 V617F Mutation Analysis
*Build Your Own Panel Eligible [?]
|
$910
|
|
Description:
- Detects gene changes in blood.
- Checks for blood disorder risk.
- Identifies mutations in blood cells.
Categories:
Price:
$910
|
|
Japanese Cedar (t17) IgE
*Build Your Own Panel Eligible [?]
|
$49
|
|
|
Description:
This test quantifies an individual's IgE response to Japanese cedar. Allergen-specific serum IgE testing is considered comparable to skin testing and may be preferred in some clinical situations. However, a positive test result only indicates that a patient is sensitized to the allergen of concern. Many IgE-sensitized individuals do not develop any symptoms when exposed to the allergen. A diagnosis of allergy should only be made by a trained medical provider after conducting a thorough clinical evaluation [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
|
|
JC Polyoma Virus DNA, Qualitative Real-Time PCR, Serum or Plasma
*Build Your Own Panel Eligible [?]
|
$435
|
|
|
Description:
JC polyoma virus is the cause of progressive multifocal leukoencephalopathy (PML), a demyelinating neurologic disease of immunosuppressed patients. This test detects JC Polyoma Virus DNA in serum or plasma. Detection of virus in specimens from AIDS and other severely immune compromised patients may indicate disease. Serum antibodies are not helpful in diagnosing PML as antibodies are common in the general population. JCV can also be detected in the urine of 3% of pregnant women, but is not associated with proven disease.
Categories:
Price:
$435
|
|
JC Polyoma Virus DNA, Qualitative, Real-Time PCR, Urine
*Build Your Own Panel Eligible [?]
|
$679
|
|
|
Description:
JC Polyoma Virus is the cause of progressive multifocal leukoencephalopathy (PML), a demyelinating neurologic disease of immunosuppressed patients. This test detects JC Polyoma Virus DNA in urine. Detection of the virus in specimens from AIDS and other severely immune compromised patients may indicate disease. Serum antibodies are not helpful in diagnosing PML as antibodies are common in the general population. JCV can also be detected in the urine of 3% of pregnant women, but is not associated with proven disease.
Categories:
Price:
$679
|
|
JC Polyoma Virus DNA, Quantitative Real-Time PCR, Serum/Plasma
*Build Your Own Panel Eligible [?]
|
$770
|
|
|
Description:
JC Polyoma Virus is the cause of Progressive Multifocal Leukoencephalopathy (PML), a severe demyelinating disease of the central nervous system. PML is a particular concern for individuals infected with the human immunodeficiency virus. Quantification of JC virus DNA is based upon the real-time PCR amplification and detection of JCV genomic DNA. Reportable range is 50 to 50,000,000 IU/mL (1.70 to 7.70 Log IU/mL).
Categories:
Price:
$770
|
