Methylmalonic Acid and Homocysteine
*Build Your Own Panel Eligible [?]
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$126
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Description:
To diagnose and monitor vitamin B12 (cobalamin) deficiency.
Categories:
Price:
$126
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Methylmalonic Acid, Urine with Creatinine
*Build Your Own Panel Eligible [?]
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$323
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Description:
- Assess energy drops and tiredness causes
- Evaluate possible nerve or muscle issues
- Monitor risk for memory or thinking problems
Includes:
Methylmalonic Acid, Urine with Creatinine
Patient Instructions:
Do not use preservatives
Categories:
Price:
$323
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Mexiletine, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$318
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Description:
Therapeutic Drug Monitoring
Categories:
Price:
$318
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Microalbumin, Random Urine with Creatinine
*Build Your Own Panel Eligible [?]
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$77
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Description:
Measurement of albumin levels in urine below the detection level of urine dipsticks. This test is useful in the management of patients with relatively early diabetes mellitus to assist in avoiding or delaying the onset of diabetic renal disease.
Microalbumin is albumin excreted in the urine and is a sensitive marker of nephropathy. It is used to screen for early renal disease in diabetic patients.
Creatinine is the endproduct of creatine metabolism. Creatine is present primarily in muscle and the amount of creatinine produced is related to total skeletal muscle mass. Daily creatinine production is fairly constant except when there is massive injury to muscle. The kidneys excrete creatinine very efficiently and blood levels and daily urinary excretion of creatinine fluctuates very little in healthy normal people. Since blood and daily urine excretion of creatinine shows minimal fluctuation, creatinine excretion is useful in determining whether 24-hour urine specimens for other analytes (e.g., protein) have been completely and accurately collected.
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Microalbumin, Random Urine with Creatinine
Patient Instructions:
Exercise within 24 hours, infection, fever, congestive heart failure, marked hyperglycemia, and marked hypertension may elevate urinary albumin excretion over baseline values.
Estimated turnaround for results is 4 business days.
If confirmation testing is required, the estimated time may be extended.
Categories:
Diabetes blood testing,
Price:
$77
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Micronutrient, Arsenic, Blood
*Build Your Own Panel Eligible [?]
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$100
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Description:
This assay is used to monitor exposure to arsenic, wellness, and therapy during treatment of chronic myelocytic leukemia.
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Price:
$100
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Micronutrient, Cadmium, Blood
*Build Your Own Panel Eligible [?]
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$80
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Description:
Cadmium is a naturally occurring element that is mined and used in industrial production because of its durability. Excessive cadmium exposure can damage lungs, kidneys, and the digestive tract.
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Price:
$80
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Micronutrient, Calcium
*Build Your Own Panel Eligible [?]
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$49
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Description:
Serum calcium is involved in the regulation of neuromuscular and enzyme activity, bone metabolism and blood coagulation. Calcium blood levels are controlled by a complex interaction of parathyroid hormone, vitamin D, calcitonin and adrenal cortical steroids. Calcium measurements are useful in the diagnosis of parathyroid disease, some bone disorders and chronic renal disease. A low level of calcium may result in tetany.
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Price:
$49
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Micronutrient, Chromium, Blood
*Build Your Own Panel Eligible [?]
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$119
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Description:
This assay is useful to monitor exposure to chromium, progress of medical treatment or to determine nutritional status.
Categories:
Price:
$119
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Micronutrient, Copper, Plasma
*Build Your Own Panel Eligible [?]
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$60
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Description:
Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions and during the third trimester of pregnancy. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.
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Price:
$60
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Micronutrient, Folate
*Build Your Own Panel Eligible [?]
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$49
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Description:
- Check vitamin B9 nutrient levels
- Screen for fatigue related causes
- Monitor pregnancy nutrient health
Categories:
Price:
$49
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Micronutrient, Iron
*Build Your Own Panel Eligible [?]
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$49
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Description:
Serum measurements are useful in the diagnosis of iron deficiency and hemochromatosis.
Categories:
Price:
$49
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Micronutrient, Lead, Blood (Venous)
*Build Your Own Panel Eligible [?]
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$49
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Description:
Blood lead level analysis is performed to evaluate the body burden of lead.
Categories:
Price:
$49
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Micronutrient, Magnesium, RBC
*Build Your Own Panel Eligible [?]
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$73
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Description:
Magnesium is an essential trace element. Deficiency leads to irritability, neuromuscular abnormalities, cardiac and renal damage. Its salts are used as antacids and cathartics. Excessive amount may cause CNS depression, loss of muscle tone, respiratory and cardiac arrest.
Categories:
Price:
$73
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Micronutrient, Manganese, Blood
*Build Your Own Panel Eligible [?]
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$430
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Description:
Manganese deficiency produces growth disorders, alters skeletal and cartilage formation and impairs reproduction. Industrial workers absorb manganese mainly through the lungs.
Categories:
Price:
$430
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Micronutrient, Mercury, Blood
*Build Your Own Panel Eligible [?]
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$100
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Description:
Mercury, a highly toxic metal, is present in select industrial environments and in contaminated ocean fish.
Categories:
Price:
$100
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Micronutrient, Molybdenum, Blood
*Build Your Own Panel Eligible [?]
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$320
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Description:
Molybdenum is an essential trace element. In anemia, molybdenum concentration decreases in both erythrocytes and plasma. Toxic doses can cause anemia and abnormal copper metabolism.
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Price:
$320
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Micronutrients, Antioxidants Panel
*Build Your Own Panel Eligible [?]
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$319
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Description:
- Check vitamin and mineral deficiencies
- Assess your antioxidant protection levels
- Monitor energy and immune function
Categories:
Price:
$319
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Micronutrients, B-Vitamin Panel
*Build Your Own Panel Eligible [?]
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$389
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Description:
- Check energy and fatigue causes
- Screen for nerve tingling issues
- Assess diet and nutrient gaps
Categories:
Price:
$389
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Micronutrient, Selenium, Blood
*Build Your Own Panel Eligible [?]
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$288
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Description:
Selenium (Se) is a key component of a number of functional selenoproteins required for normal health. The best known of these are the antioxidant glutathione peroxidase enzymes, which remove hydrogen and damaging lipid and phospholipid hydroperoxides generated in vivo by free radicals and other oxygen-derived species. If not removed, lipid hydroperoxides impair membrane structure and function and cause blood-clotting disturbances by decreasing the production of prostacyclin while increasing the production of thromboxane.
Categories:
Price:
$288
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Micronutrients, Heavy Metals Panel, Blood
*Build Your Own Panel Eligible [?]
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$356
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Description:
- Check vitamin and mineral deficiencies
- Screen for toxic heavy metal exposure
- Assess energy and immune health
Categories:
Price:
$356
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Micronutrients, Mineral/Element Panel
*Build Your Own Panel Eligible [?]
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$851
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Description:
- Check mineral and nutrient deficiencies
- Screen for low energy causes
- Assess immune and bone health
Categories:
Price:
$851
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Micronutrient, Vitamin A (Retinol)
*Build Your Own Panel Eligible [?]
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$51
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Description:
Vitamin A is critical for vision, growth and many cell functions. High concentrations of Vitamin A are seen with renal failure, but this is not associated with toxicity and excessive ingestion. High concentrations are associated with bone fractures. Low concentrations of Vitamin A are consistent with fat malabsorption and are rarely due to inadequate diet.
Categories:
Price:
$51
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Micronutrient, Vitamin B12
*Build Your Own Panel Eligible [?]
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$49
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Description:
B12 is decreased in pernicious anemia, total or partial gastrectomy, malabsorption and certain congenital and biochemical disorders.
Categories:
Price:
$49
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Micronutrient, Vitamin B1 (Thiamine), Blood
*Build Your Own Panel Eligible [?]
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$100
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Description:
Vitamin B1 is required for branched-chain amino acid and carbohydrate metabolism. Vitamin B1 deficiency is most often due to alcoholism or chronic illness. In the early stage, patients with vitamin B1 deficiency exhibit anorexia, irritability, apathy, and generalized weakness. Prolonged deficiency causes beriberi.
Categories:
Price:
$100
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Micronutrient, Vitamin B2
*Build Your Own Panel Eligible [?]
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$120
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Description:
Vitamin B2 is involved in metabolism of fats, carbohydrates, and protein. The clinical manifestations of deficiency are non-specific. Clinical manifestations include mucocutaneous lesions of the mouth and skin, corneal vascularization, anemia, and personality changes.
Categories:
Price:
$120
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Micronutrient, Vitamin B3
*Build Your Own Panel Eligible [?]
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$132
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Description:
Vitamin B3 occurs naturally in plants and animals and is also added to many foods as a vitamin supplement.
Categories:
Price:
$132
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Micronutrient, Vitamin B5
*Build Your Own Panel Eligible [?]
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$136
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Description:
Vitamin B5 (Pantothenic Acid) is a component of coenzyme A and phosphopantetheine both of which are involved in fatty acid metabolism. It is essential to almost all forms of life and is widely distributed in food.
Categories:
Price:
$136
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Micronutrient, Vitamin C
*Build Your Own Panel Eligible [?]
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$114
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Description:
Vitamin C is an antioxidant involved in connective tissue metabolism, drug-metabolizing systems, and mixed-function oxidase systems to list a few. Vitamin C deficiency causes scurvy; manifestations include impaired formation of mature connective tissue, bleeding into the skin, weakness, fatigue, and depression.
Categories:
Price:
$114
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Micronutrient, Vitamin E
*Build Your Own Panel Eligible [?]
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$84
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Description:
Deficiency of Vitamin E may cause extensive neuropathy in young children and, in addition, is suspect as a possible cause of motor and sensory neuropathy in older children and in adults. One likely cause of Vitamin E deficiency is intestinal malabsorption, resulting from bowel disease, pancreatic disease, or chronic cholestasis. Other causes of malabsorption of Vitamin E include celiac disease, cystic fibrosis, and intestinal lymphangiectasia.
Categories:
Price:
$84
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Micronutrient, Zinc, Plasma
*Build Your Own Panel Eligible [?]
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$49
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Description:
Zinc is an essential element involved in a myriad of enzyme systems including wound healing, immune function, and fetal development. Zinc measurements are used to detect and monitor industrial,dietary, and accidental exposure to zinc. Also, zinc. measurements may be used to evaluate health and monitor response to treatment.
Categories:
Price:
$49
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Microsatellite Instability (MSI)
*Build Your Own Panel Eligible [?]
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$1040
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Description:
Patients with early onset and family history of colon cancers are suggestive of hereditary nonpolyposis colon cancer (hnpcc) syndrome. Microsatellite instability analysis on tumor tissue is recommended as a screening test to identify individuals eligible for germline mutation analysis or mismatch repair genes. Microsatellite instability analysis can also be used to identify adult and pediatric patients with unrespectable or metastatic solid tumors who have failed frontline therapy and who would be candidates for targeted immune therapy with Keytruda (Pembrolizumab).
Categories:
Price:
$1040
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Microsporidia Exam
*Build Your Own Panel Eligible [?]
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$162
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Description:
Microsporidia infection was first recognized as a cause of chronic diarrhea in patients infected with HIV. Microsporidia may also cause pneumonia, acute bilateral keratoconjunctivitis, and infection of the biliary and pancreatic ducts.
Categories:
Price:
$162
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Milk Component Panel
*Build Your Own Panel Eligible [?]
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$173
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Description:
For use in the identification and severity of which specific milk protein a patient is allergic. This knowledge enables the clinician and the patient to make the correct treatment and lifestyle choices to mitigate exposure and reaction risk.
Categories:
Price:
$173
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Milk Cow IgG4
*Build Your Own Panel Eligible [?]
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$254
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Description:
The clinical utility of food-specific IgG4 tests has not been clearly established. Physicians sometimes use allergen-specific IgG4 to evaluate patients prior to or during immunotherapy. These tests can be used in special clinical situations. This test should only be ordered by physicians who recognize the limitations of the test.
Categories:
Price:
$254
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Miller Fisher Syndrome, Cranial Neuropathy Antibody Panel (Ganglioside)
*Build Your Own Panel Eligible [?]
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$954
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Description:
Ganglioside GM-1 IgG antibody is associated with acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. GD1a IgG antibody may also be associated with acute motor axonal neuropathy. GD1b IgG antibody may be associated with acute motor and sensory axonal neuropathy with cerebellar ataxia or ataxic presentations of Guillain-Barré Syndrome. GQ1b IgG antibody is associated with the Miller-Fisher Syndrome.
Categories:
Price:
$954
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Mineral Profile, RBCs
*Build Your Own Panel Eligible [?]
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$634
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Description:
- Checks minerals in red blood cells.
- Assesses mineral balance in body.
- Monitors essential nutrients in blood.
Categories:
Price:
$634
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Mint (Mentha piperita) (f332) IgE
*Build Your Own Panel Eligible [?]
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$80
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Description:
- Pinpoint your mint allergy triggers effectively
- Clarify the cause of your digestive issues
- Reveal hidden factors behind your skin reactions
Categories:
Allergy blood testing,
Price:
$80
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Mirtazapine, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$346
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Description:
Therapeutic drug monitoring.
Categories:
Price:
$346
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MITF-1, IHC with Interpretation
*Build Your Own Panel Eligible [?]
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$442
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Description:
Transcription factor involved in pigmentation, expressed in malignant melanoma.
Categories:
Price:
$442
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MITF-1, IHC without Interpretation
*Build Your Own Panel Eligible [?]
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$370
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Description:
Transcription factor involved in pigmentation, expressed in malignant melanoma.
Categories:
Price:
$370
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MITF Gene Analysis
*Build Your Own Panel Eligible [?]
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$628
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Description:
This test includes analysis of the c.952G>A; p.Glu318Lys variant in the MITF gene. Individuals with this pathogenic variant have an elevated risk of melanoma and renal cell carcinoma.
Categories:
Price:
$628
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Mitochondrial Antibody with Reflex to Titer
*Build Your Own Panel Eligible [?]
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$196
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Description:
A high Anti-Mitochondrial Antibody (AMA) titer supports the diagnosis of primary biliary cirrhosis (PBC). Low titers of AMA may be detected in other liver disorders, which include chronic active hepatitis and cryptogenic cirrhosis. Mitochondrial M2 Antibody has an even higher specificity for PBC.
Alternative names: Anti-Mitochondrial Antibody,AMA, Mitochondrial Antibody with Reflex
Categories:
Gastrointestinal diseases,
Infectious diseases,
Price:
$196
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Mitochondria M2 Antibody (IgG), EIA
*Build Your Own Panel Eligible [?]
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$281
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Description:
- Checks for liver-related antibodies
- Detects autoimmune liver disease markers
- Identifies liver cell damage indicators
Includes:
Mitochondria M2 Antibody (IgG), EIA
Categories:
Price:
$281
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Mitogen- and Antigen-induced Lymphocyte Proliferation Panel
*Build Your Own Panel Eligible [?]
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$2596
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Description:
Measurement of human lymphocytes' proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. Mitogens, such as plant lectins phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), are able to nonspecifically stimulate lymphocyte proliferation and used to evaluate patient immune responsiveness. Lymphocyte proliferation response to antigens, such as Candida, tetanus toxoid and tuberculin purified protein derivative (PPD), are evaluated as a function of memory in cell-mediated immunity.
Categories:
Price:
$2596
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Mitogen-induced Lymphocyte Proliferation Panel (PHA, Con A, PWM)
*Build Your Own Panel Eligible [?]
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$888
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Description:
Measurement of human lymphocytes' proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. Mitogens, such as plant lectins phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), are able to nonspecifically stimulate lymphocyte proliferation and used to evaluate patient immune responsiveness.
Categories:
Price:
$888
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Mitotane, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$368
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Description:
- Monitor mitotane drug treatment levels
- Check adrenal cancer medication dosing
- Track treatment progress over time
Categories:
Price:
$368
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Mixed Connective Tissue Disease Panel (RNP Antibody and ANA with Reflex)
*Build Your Own Panel Eligible [?]
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$334
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Description:
This panel can be helpful in the diagnosis of individuals with clinical suspicion of mixed connective tissue disease (MCTD). All specimens are tested for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells; and RNP antibodies with a multiplex immunoassay. For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.The laboratory evaluation for individuals with clinical suspicion of autoimmune diseases often begins with an ANA screen. The classic ANA IFA on HEp-2 cells is considered by the American College of Rheumatology (ACR) as the current gold standard because of its overall high sensitivity for several autoimmune diseases [1]. Knowing the ANA titer and fluorescent staining pattern can be helpful in interpreting positive results [2]. The first indication of MCTD is often a high ANA titer (>1:1000), which occurs in 94% to 97% of patients with MCTD [3]. The presence of RNP antibodies is considered the serologic hall mark of MCTD and required by diagnostic criteria [3].Individuals with negative results on the ANA IFA usually also have negative results on specific autoantibodies. Therefore, subserology testing is not recommended for individuals without positive ANA IFA results and clinical suspicion of relevant autoimmune disease [4]. However, Jo-1 antibody may be detected in ANA IFA-negative patients with some types of myositis, and SSA antibody may be detected in some ANA IFA-negative patients with lupus or Sjogren syndrome [4].The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Methodology of testing for antinuclear antibodies (position statement). 2009. American College of Rheumatology. Updated December 2019. Accessed May 15, 2023. https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/blta48818378bc89445/acr-position-statement-methodology-testing-antinuclear-antibodies.pdf2. Tozzoli R, et al. Am J Clin Pathol. 2002;117(2):316-324.3. Cappelli S, et al. Semin Arthritis Rheum. 2012;41(4):589-598.4. Yazdany J, et al. Arthritis Care Res (Hoboken). 2013;65(3):329-339.
Categories:
Price:
$334
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Mixing Study
*Build Your Own Panel Eligible [?]
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$411
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Description:
This test is used to help differentiate coagulation factor deficiency from inhibitor activity in patients with prolonged clotting times-prothrombin time (PT) and activated partial thromboplastin time (aPTT).Deficiency of a coagulation factor or factors can be congenital or acquired. Congenital factor deficiency is caused by pathogenic variants of the gene that encodes the coagulation factor; acquired factor deficiency is caused by inhibitors that interfere with factor activity. This mixing study can be used to determine the cause of factor deficiency. If the clotting time of the immediate mix remains prolonged ("not corrected"), the presence of an inhibitor is suspected (ie, lupus anticoagulant, factor specific inhibitors, anticoagulant, or other non-specific inhibitors). If the clotting time of the immediate mix is below the cut-off ("corrected"), a factor deficiency is suspected. Because some inhibitors (eg, inhibitors against factor VIII) can only be detected after incubation, an incubated mix may also be included with the aPTT mixing study [1].This test can be used to guide the investigation of coagulation disorders but has limited sensitivity and specificity [1], specifically if the baseline clotting test is minimally prolonged. Tests for coagulation factors, specific inhibitors, and lupus anticoagulants may be needed for the diagnosis.Note that the test results may be affected by the titer and strength of inhibitors, number of the deficient coagulation factors, heparin contamination, anticoagulants, direct thrombin inhibitors, or direct Xa inhibitors [1].The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.Reference1. Higgins RA, et al. Coagulation, anticoagulation, fibrinolysis. In: Rifai R, et al, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier Inc; 2022.
Categories:
Price:
$411
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MLH1, IHC with Interpretation
*Build Your Own Panel Eligible [?]
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$442
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Description:
This immunohistochemistry (IHC) assay is based on an antibody directed against the DNA mismatch repair (MMR) protein MLH1. MLH1 IHC testing is usually done as part of a panel that assesses expression of 4 MMR proteins (the other 3 are MSH2, MSH6, and PMS2) in resected tumor tissue from patients with newly diagnosed colorectal or endometrial cancer. Loss of expression of 1 or more of these proteins may indicate defective DNA repair processes associated with Lynch syndrome [1,2].IHC for MMR proteins is generally performed on tissue from certain tumors (eg, colorectal carcinomas and endometrial carcinomas) to screen for Lynch syndrome. IHC testing of MMR proteins identifies approximately 95% of tumors with defective MMR [1]. DNA microsatellite instability (MSI) is another testing methodology that may help screen for patients with Lynch syndrome. MSI-high results and/or loss of expression of any MMR protein (except MLH1) can be followed by germline pathogenic variant testing of the relevant genes to confirm Lynch syndrome [1].Loss of MLH1 expression may reflect germline mutation in the MLH1 gene (in the setting of Lynch syndrome) or MLH1 promotor methylation and BRAF mutation (in the setting of sporadic tumorigenesis). Therefore, in patients with loss of MLH1 expression, testing tumor tissue for a BRAF mutation or for hypermethylation of the MLH1 promoter may be performed before proceeding to germline genetic testing for Lynch syndrome. In patients with high suspicion of Lynch syndrome, genetic testing should be considered despite normal screening results [2].The results of IHC of MMR proteins and MSI may also be useful in evaluating chemotherapy and immunotherapy choices for many solid tumors.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Baine MK, et al. Immunohistochemical testing of DNA mismatch repair (MMR) proteins. In: Rekhtman N, et al. Quick Reference Handbook for Surgical Pathologists.2nd ed. Springer; 2011:35.2. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN Guidelines®). Genetic/familial high-risk assessment: colorectal. V1.2021. Accessed November 22, 2021. http://www.nccn.org
Categories:
Price:
$442
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MLH1, IHC without Interpretation
*Build Your Own Panel Eligible [?]
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$370
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Description:
This immunohistochemistry (IHC) assay is based on an antibody directed against the DNA mismatch repair (MMR) protein MLH1. MLH1 IHC testing is usually done as part of a panel that assesses expression of 4 MMR proteins (the other 3 are MSH2, MSH6, and PMS2) in resected tumor tissue from patients with newly diagnosed colorectal or endometrial cancer. Loss of expression of 1 or more of these proteins may indicate defective DNA repair processes associated with Lynch syndrome [1,2].IHC for MMR proteins is generally performed on tissue from certain tumors (eg, colorectal carcinomas and endometrial carcinomas) to screen for Lynch syndrome. IHC testing of MMR proteins identifies approximately 95% of tumors with defective MMR [1]. DNA microsatellite instability (MSI) is another testing methodology that may help screen for patients with Lynch syndrome. MSI-high results and/or loss of expression of any MMR protein (except MLH1) can be followed by germline pathogenic variant testing of the relevant genes to confirm Lynch syndrome [1].Loss of MLH1 expression may reflect germline mutation in the MLH1 gene (in the setting of Lynch syndrome) or MLH1 promotor methylation and BRAF mutation (in the setting of sporadic tumorigenesis). Therefore, in patients with loss of MLH1 expression, testing tumor tissue for a BRAF mutation or for hypermethylation of the MLH1 promoter may be performed before proceeding to germline genetic testing for Lynch syndrome. In patients with high suspicion of Lynch syndrome, genetic testing should be considered despite normal screening results [2].The results of IHC of MMR proteins and MSI may also be useful in evaluating chemotherapy and immunotherapy choices for many solid tumors.The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Baine MK, et al. Immunohistochemical testing of DNA mismatch repair (MMR) proteins. In: Rekhtman N, et al. Quick Reference Handbook for Surgical Pathologists. 2nd ed. Springer; 2011:35.2. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN Guidelines®). Genetic/familial high-risk assessment: colorectal. V1.2021. Accessed November 22, 2021. http://www.nccn.org
Categories:
Price:
$370
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