Pediatric Autoimmune Encephalitis Evaluation with Reflexes, Serum
*Build Your Own Panel Eligible [?]
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$4121
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Description:
Causes of autoimmune encephalitis differ between adults and children, largely due to the fact that autoimmune encephalitis in adults is more likely to be due to cancer, but in children more likely to have been caused by a viral infection. This panel will assess the most common causes of autoimmune encephalitis/encephalomyelitis in the pediatric age group.
Includes:
- Aquaporin-4 (AQP4) Antibody, CBA with Reflex to Titer, Serum
- Collapsin Response-Mediator Protein-5(CRMP5/CV2) Antibody, Line Blot
- Glutamic Acid Decarboxylase (GAD65) Antibody, Line Blot
- MOG Antibody, CBA with Reflex to Titer, Serum
- NMDAR1 Antibody, CBA with Reflex to Titer, Serum
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Price:
$4121
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Penicillium Chrysogenum/notatum IgG
*Build Your Own Panel Eligible [?]
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$228
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Description:
Although there have been many publications concerning the measurement of allergen-specific IgG, the clinical utility of such test has not been established except in special situations. Thus, the quantitative IgG test should only be ordered by specialists who recognize the limitations of the test. The normal reference ranges reported represent the expected results for individuals who have no unusual exposure and have not been immunized with the indicated allergen. The ranges reported have no disease-associated significance.
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Price:
$228
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Penicillium glabrum (p. frequentans) (m209) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against Penicillium glabrum. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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Penicillium notatum/chrysogenum IgG4
*Build Your Own Panel Eligible [?]
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$254
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Description:
- Detect mold-related immune reactions
- Screen for hidden allergy triggers
- Track symptoms linked to mold exposure
Categories:
Price:
$254
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Penicillium notatum (m1) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This allergen-specific IgE antibody test quantifies an individualโs IgE response to Penicillium notatum. It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. More specific information about this allergen can be found at http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/Molds-and-other-Microorganisms/Allergens/Penicillium-chrysogenum/ Reference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(Suppl 3):S1-S148.
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Price:
$49
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Penicilloylย G and V Profile
*Build Your Own Panel Eligible [?]
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$89
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Description:
This allergen-specific IgE antibody panel quantifies an individual's IgE response to penicilloyl G (major allergenic determinant of penicillin G) and penicilloyl V (major allergenic determinant of penicillin V). It is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1].While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include (1) the presence of widespread skin disease, (2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, (3) uncooperative patients, and (4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1].A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated.More specific information about these allergens can be found at https://www.thermofisher.com/diagnostic-education/hcp/us/en/resource-center/allergen-encyclopedia/whole-allergens.html?key=c1 and https://www.thermofisher.com/diagnostic-education/hcp/us/en/resource-center/allergen-encyclopedia/whole-allergens.html?key=c2.Reference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3)S1-S148.
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Price:
$89
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Penicilloyl G (c1) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against penicilloyl G (major allergenic determinant of penicillin G). A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
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Penicilloyl V (c2) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against penicilloyl V (major allergenic determinant of penicillin V). A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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Pentaย Screen
*Build Your Own Panel Eligible [?]
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$1295
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Description:
- Screen for five common substances
- Check your drug-free status privately
- Verify results for employment requirements
Categories:
Price:
$1295
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Pentobarbital
*Build Your Own Panel Eligible [?]
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$326
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Description:
- Check sedative drug blood levels
- Screen for unsafe medication exposure
- Monitor prescribed sedative safety levels
Categories:
Price:
$326
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Pepper Bell/Paprika (Capsicum annum) IgG
*Build Your Own Panel Eligible [?]
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$228
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Description:
- Detect bell pepper food sensitivity
- Screen for hidden digestive triggers
- Track skin and gut reactions
Categories:
Price:
$228
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Peppertree (rt217) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
The determination of allergen-specific IgE Ab is a very sensitive first-order test for allergic disease. The presence of IgE Ab to peppertree is highly predictive of the likelihood that the individual will exhibit immediate hypersensitivity upon exposure to the allergen.
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Price:
$49
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Peptide Baseline Blood Test Panel
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$129
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Description:
Before you start a peptide cycle, get a baseline you can compare against later. This peptide baseline blood test panel checks IGF-1, hs-CRP, comprehensive metabolic panel (CMP), and CBC with differential and platelets so you can see where your key response and safety markers stand before anything changes. IGF-1 is the main marker people look at when tracking growth-hormone peptide response, including peptides such as sermorelin, ipamorelin, and CJC-1295. If you repeat testing during or after a cycle, your IGF-1 blood test result gives you a measurable point of comparison instead of relying only on how you feel. hs-CRP is a high-sensitivity inflammation marker. It helps establish your body-wide inflammation baseline before peptide use and gives you another number to compare if you test again later. The comprehensive metabolic panel, or CMP blood test, adds liver, kidney, glucose, protein, and electrolyte markers. These are useful safety markers before starting or changing a protocol. The CBC adds blood-count context, including red blood cells, white blood cells, and platelets. This panel does not measure peptide compounds directly and does not tell you what dose to use. It gives you baseline blood work and follow-up comparison data that you can review with a qualified healthcare provider.
Patient Instructions:
You should fast for 12 hours before collection of the specimen. Fasting is defined as no consumption of food or beverage other than water for at least 12 hours before testing.
Estimated turnaround for results is 7 business days. If confirmation testing is required, the estimated time may be extended.
Categories:
Hormones & metabolism,
Price:
$129
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Perampanel, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$478
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Description:
Therapeutic drug monitoring.
Categories:
Price:
$478
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Perennial Rye Grass (g5) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test quantifies an individualโs IgE response to perennial rye grass. It is an in vitro quantitative assay, which is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method, but should be made by a trained healthcare professional after all clinical and laboratory findings have been evaluated. More specific information about this allergen can be found at http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/Grass-Pollens/Allergens/Rye-grass-/ Reference 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(suppl 3):S1-S148.
Categories:
Price:
$49
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Perfluorooctanoic Acid, Blood
*Build Your Own Panel Eligible [?]
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$1050
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Description:
Exposure monitoring.
Categories:
Price:
$1050
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Pernicious Anemia Diagnostic Panel
*Build Your Own Panel Eligible [?]
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$352
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Description:
This panel tests for anti-intrinsic factor antibodies, vitamin B12, and methylmalonic acid (MMA) and can be used to identify pernicious anemia as the cause of vitamin B12 deficiency. In patients with clinical suspicion of pernicious anemia, the combination of megaloblastic anemia, presence of anti-intrinsic factor antibodies, low level of vitamin B12, and/or high level of MMA confirms the diagnosis [1,2].Pernicious anemia is one of many conditions that lead to vitamin B12 deficiency. Pernicious anemia is caused by the immune system targeting intrinsic factors or parietal cells that make intrinsic factors. Lack of intrinsic factors results in decreased absorption of vitamin B12, a vitamin that is essential for erythropoiesis. Initial screening for vitamin B12 deficiency usually starts with a complete blood count and serum vitamin B12 level. MMA levels represent a more direct measure of the physiologic activity of vitamin B12. Therefore, MMA measurement may help in evaluating vitamin B12 deficiency when the vitamin B12 level is normal or low-normal-particularly when macrocytosis is found [1].Anti-intrinsic factor antibodies, found in 40% to 60% of patients with pernicious anemia, are highly specific for pernicious anemia [2]. Therefore, testing for intrinsic factor antibodies may be helpful when dietary vitamin B12 deficiency or malabsorption cannot be identified as the cause of vitamin B12 deficiency. This is especially true for patients with anemia, neuropathy, glossitis, or other autoimmune disorders (eg, Hashimoto disease, type 1 diabetes, vitiligo, and hypoadrenalism). The presence of intrinsic factor antibodies with confirmed vitamin B12 deficiency has a high positive predictive value (95%) for pernicious anemia [1,2].The components of this panel can be ordered individually. The intrinsic factor antibodies test has relatively low sensitivity (40%-60%); thus, a negative result does not rule out pernicious anemia [2]. In patients with negative results for intrinsic factor antibodies but confirmed vitamin B12 deficiency and strong clinical suspicion of pernicious anemia, a high serum gastrin level is consistent with the diagnosis [1].The results of this test should be interpreted in the context of pertinent clinical and physical examination findings.References1. Langan RC, et al. Am Fam Physician. 2017;96(6):384-389.2. Devalia V, et al; British Committee for Standards in Haematology. Br J Haematol. 2014;166(4):496-513.
Categories:
Price:
$352
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Perphenazine, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$328
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Description:
Perphenazine is a phenothiazine for treating psychosis. Monitoring its level is important to optimize therapy, to avoid toxicity, and to assure compliance.
Categories:
Price:
$328
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Persimmon (Kaki Fruit) (f301) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test is an allergen-specific IgE antibody test that quantifies an individualโs IgE response to persimmon (Kaki fruit). It is an in vitro quantitative assay, which is intended to be used in conjunction with other clinical information to aid in the diagnosis of food allergy [1]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include 1) the presence of widespread skin disease, 2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, 3) uncooperative patients, and 4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [1]. Food-specific IgE tests are extremely sensitive. However, a positive test result only indicates that a patient is IgE sensitized to the food of concern. Many IgE-sensitized patients do not develop any symptoms when this food is ingested. A diagnosis of food allergy should only be made by a trained medical provider, after conducting a thorough clinical evaluation [2,3]. While food-specific IgE test results may contribute to that evaluation, they cannot replace it. In this regard, detection of food-specific IgE in serum provides evidence of IgE sensitization, but a history of clinical reactivity to the food of concern, is required to make a diagnosis of IgE-mediated food allergy. Moreover, several forms of food hypersensitivity are not associated with the presence of food-specific IgE in serum. More specific information about this allergen can be found at http://www.phadia.com/en/products/allergy-testing-products/immunocap-allergen-information/food-of-plant-origin/fruits/persimon-kaki-fruit-sharon-/ References 1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(suppl 3):S1-S148. 2. Sampson HA, et al. J Allergy Clin Immunol. 2014;134:1016-1025. 3. Boyce JA, et al. J Allergy Clin Immunol. 2010;126(6 suppl):S1-S58.
Categories:
Price:
$49
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Phencyclidine, Serum/Plasma
*Build Your Own Panel Eligible [?]
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$326
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Description:
- Detect recent PCP drug exposure
- Confirm substance use privately today
- Screen for phencyclidine in blood
Categories:
Price:
$326
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Phenobarbital
*Build Your Own Panel Eligible [?]
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$187
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Description:
Phenobarbital is an anticonvulsant used for the long-term treatment of generalized tonic-clonic (grand mal) seizures and cortical focal seizures. Phenobarbital levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
Categories:
Price:
$187
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Phenylalanine
*Build Your Own Panel Eligible [?]
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$304
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Description:
- Check amino acid and protein balance
- Monitor energy and mood levels
- Assess dietary protein processing efficiency
Categories:
Price:
$304
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Phenylalanine and Tyrosine
*Build Your Own Panel Eligible [?]
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$458
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Description:
- Check amino acid and metabolism balance
- Screen for energy and mood issues
- Assess protein processing efficiency
Categories:
Price:
$458
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Phenylketonuria (PKU) Gene Sequencing
*Build Your Own Panel Eligible [?]
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$4610
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Description:
1. To identify disease-causing variants in individuals affected with PKU. 2. To identify carriers in high risk ethnic groups or people with a positive family history. 3. Prenatal diagnosis of PKU.
Categories:
Price:
$4610
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Phenytoin
*Build Your Own Panel Eligible [?]
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$212
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Description:
Phenytoin is an anticonvulsant hydantoin used for the treatment of generalized tonic-clonic (grand mal) and complex partial seizures. Phenytoin is also used for prophylaxis in neurosurgical procedures. Phenytoin levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.
Categories:
Price:
$212
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Phenytoin, Free
*Build Your Own Panel Eligible [?]
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$150
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Description:
Phenytoin is used singly or in combination with other anticonvulsants to treat grand mal epilepsy. Monitoring the serum levels of antiepileptic drugs has increased the efficiency and safety of drug therapy in epilepsy. It facilitates individualization of dosage regimen, reveals irregular drug intake and identifies the responsible agent in intoxicated patients on multiple drug therapy. Free phenytoin is especially useful in patients with altered phenytoin binding to protein, e.g., uremia or individuals having abnormally low levels of albumin, such as nephrotic syndrome. Free phenytoin in serum correlates better with the various other free compartments of the body than does the total drug and is probably a better estimate of the "active drug level" at the receptor site and agrees more with the clinical response.
Categories:
Price:
$150
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pH, Feces
*Build Your Own Panel Eligible [?]
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$219
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Description:
This test may help evaluate carbohydrate malabsorption as the cause of osmotic diarrhea [1]. Osmotic diarrhea is caused by the osmotic effect of a substance that retains water in the intestine lumen. Conditions associated with osmotic diarrhea include ingesting poorly absorbed solutes (eg, sorbitol, mannitol, laxatives containing magnesium) and enzyme dysfunction (eg, lactose intolerance) [1]. In patients with osmotic diarrhea, a stool pH 5.5 is most likely due to other osmotic causes but does not rule out carbohydrate malabsorption [2].Disruption of the acid-base balance has been observed in patients with various conditions, such as severe systemic inflammatory response syndrome, multiple organ failure, sepsis, and colorectal cancer. Abnormal stool pH has been correlated with higher mortality in patients treated in the intensive care unit [3]. The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.References1. Block DR, et al. Body fluids. In: Rifai R, et al, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier Inc; 2022.2. Caspary WF. Clin Gastroenterol. 1986;15(3):631-655.3. Osuka A, et al. Crit Care. 2012;16(4):R119.
Categories:
Price:
$219
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Phoma betae IgG
*Build Your Own Panel Eligible [?]
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$251
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Description:
- Pinpoint the cause of digestive issues
- Reveal hidden food sensitivities
- Clarify unexplained fatigue sources
Categories:
Allergy blood testing,
Price:
$251
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Phoma betae (m13) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against Phoma betae. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Categories:
Price:
$49
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Phosphate, 24-Hour Urine with Creatinine
*Build Your Own Panel Eligible [?]
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$212
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Description:
Phosphorus is present in many foods with a mean intake of approximately 1500 mg per day for adult males and about 1000 mg per day for adult females. Absorbed phosphate, under the influence of parathyroid hormone is readily excreted in the kidney. Measurement of urinary phosphorus generally reflects dietary intake hence, day-to-day excretion may show considerable variation.
Categories:
Price:
$212
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Phosphate,ย 24-Hourย Urine withoutย Creatinine
*Build Your Own Panel Eligible [?]
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$202
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Description:
Phosphorus is present in many foods with a mean intake of approximately 1500 mg per day for adult males and about 1000 mg per day for adult females. Absorbed phosphate, under the influence of parathyroid hormone is readily excreted in the kidney. Measurement of urinary phosphorus generally reflects dietary intake, hence, day-to-day excretion may show considerable variation.
Categories:
Price:
$202
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Phosphate (as Phosphorus)
*Build Your Own Panel Eligible [?]
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$53
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Description:
Serum phosphorus (Phosphate) levels alone are of limited diagnostic value and should be correlated with serum calcium levels. An increased phosphorus with decreased calcium suggests either hypoparathyroidism or renal disease. A decreased phosphorus and an increased calcium suggests hyperparathyroidismย or sarcoidosis. When both calcium and phosphorus are decreased diagnostic considerations include malabsorption, vitaminย D deficiency and renal tubular acidosis. Increased phosphorus and normal or increased calcium suggests Milk-alkali syndrome or hypervitaminosis D.
Alternative Name(s): Phosphorus
A significant deviation from the normal range may require further evaluation by your physician.
Includes:
Serum phosphorus.
****Phosphate (as Phosphorus) is included in the Kidney Function Profile.****
Patient Instructions:
No fasting needed.
Categories:
Musculoskeletal diseases,
General wellness,
Kidney diseases,
Gastrointestinal diseases,
Price:
$53
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Phosphate, Pediatric Urine with Creatinine
*Build Your Own Panel Eligible [?]
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$212
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Description:
The urinary phosphorus concentration is useful to assess calcium and phosphorus balance. The thyroid and kidneys are key organs whose function influence urinary phosphorus concentration.
Categories:
Price:
$212
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Phosphate,ย Random Urine without Creatinine
*Build Your Own Panel Eligible [?]
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$202
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Description:
Phosphorus is present in many foods with a mean intake of approximately 1500 mg per day for adult males and about 1000 mg per day for adult females. Absorbed phosphate, under the influence of parathyroid hormone is readily excreted in the kidney. Measurement of urinary phosphorus generally reflects dietary intake hence day to day excretion may show considerable variation.
Categories:
Price:
$202
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Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM)
*Build Your Own Panel Eligible [?]
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$415
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Description:
Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti-phospholipid antibodies (APL). The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.
Categories:
Price:
$415
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Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgG)
*Build Your Own Panel Eligible [?]
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$281
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Description:
Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti- phospholipid antibodies (APL). The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.
Categories:
Price:
$281
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Phosphatidylserine/Prothrombin (PS/PT) Antibody (IgM)
*Build Your Own Panel Eligible [?]
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$281
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Description:
Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti- phospholipid antibodies (APL). The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities, but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated.
Categories:
Price:
$281
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Phosphoethanolamine (PEA), Urine with Creatinine
*Build Your Own Panel Eligible [?]
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$779
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Description:
Hypophosphatasia (HPP) is a rare metabolic bone disease characterized by defective mineralization of bones and teeth through decreased activity of tissue non-specific alkaline phosphatase (TNSALP). Pathogenic variants in the ALPL gene on chromosome 1 lead to HPP, which can be inherited in an autosomal recessive or autosomal dominant fashion depending on the nature of the variant; the dominant form of the disease typically exhibits a mild phenotype. HPP has a range of severity, with the most severe forms presenting in infancy or even prenatally and the mildest forms presenting in adulthood. However, it should be noted that a prenatal benign form of HPP also exists. Depending on the age of onset and/or severity, HPP can be classified as either Perinatal, Infantile, Juvenile, Adult, or as Odontohypophosphatasia. In the most severe perinatal form of the disease, skeletal deformities are present at birth and can also be detected on prenatal ultrasound. The impaired bone mineralization results in skeletal abnormalities including shortening and bowing of the limbs, a narrow chest leading to hypoplastic lungs. Stillbirths are common with this severe phenotype. Most individuals with perinatal HPP did not survive. Infantile HPP presents within the first six months of life with rickets and increased bone fractures. Growth is affected and patients can experience hypercalcemia and nephrocalcinosis. Childhood HPP presents after six months of age; radiographic features are consistent with rickets and premature loss of teeth with intact roots is a characteristic finding. In adults, HPP often presents with recurrent fractures, stress fractures, slow-healing fractures, and bone and joint pain. In the mildest form of the disease, odontohypophosphatasia dental abnormalities are found in the absence of any skeletal manifestations. The severe form of the disease has an incidence of approximately 1:300,000 based on a French study; the prevalence of the milder autosomal dominant form of the disease was predicted to be as high as 1:6370 from the same study.HPP can be diagnosed by decreased activity of serum alkaline phosphatase and increased excretion of the TNSALP substrate phosphoethanolamine (PEA) in urine. Molecular analysis of the ALPL gene can also be used to establish a diagnosis of HPP. There is strong genotype-phenotype correlation.The recombinant enzyme replacement therapy (ERT) was approved by the FDA in 2015 and has been used as first-line therapy in several forms of HPP.PEA urinalysis is used to support a diagnosis of HPP, especially in patients with low alkaline phosphatase, and to monitor ERT. Several studies showed that elevated urine PEA is a specific biomarker for HPP. However, other bone diseases, some endocrine disorders and hypertension can also cause elevated urine PEA.
Categories:
Price:
$779
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Phospholipase A2 Receptor (PLA2R) Antibody, ELISA
*Build Your Own Panel Eligible [?]
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$602
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Description:
Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.
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Price:
$602
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Phospholipase A2 Receptor (PLA2R) Antibody, IFA
*Build Your Own Panel Eligible [?]
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$464
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Description:
Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.
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Price:
$464
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Phospholipase A2 Receptor (PLA2R) Antibody Panel
*Build Your Own Panel Eligible [?]
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$919
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Description:
Phospholipase A2 Receptor (PLA2R) Antibody (Ab) testing provides physicians with a non-invasive tool for diagnosing primary membranous nephritis (PMN), an autoimmune disease most commonly mediated by autoantibodies to the podocyte antigen, PLA2R. PLA2R Ab is a highly specific biomarker for PMN and is detected in about 70-80% of patients. Moreover, PLA2R Ab levels frequently rise and fall with the clinical course of PMN and PLA2R Ab levels may have clinical utility in monitoring PMN patients for therapeutic response, remission, and disease relapse.
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Price:
$919
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Phospholipids
*Build Your Own Panel Eligible [?]
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$324
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Description:
Phospholipids are used in diagnosing and treating disorders of lipid metabolism associated with atherosclerosis.
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Price:
$324
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Phthalic Anhydride (k79) IgE
*Build Your Own Panel Eligible [?]
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$80
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Description:
This allergen-specific IgE antibody test quantifies an individual's IgE response to phthalic anhydride, an organic compound widely used in the resin manufacturing. Exposure to phthalic anhydride may irritate the eyes, respiratory tract, and skin and cause occupational asthma [1]. This test is an in vitro quantitative assay that is intended to be used in conjunction with other clinical information to aid in the diagnosis of allergic diseases [2]. While allergen-specific serum IgE testing is considered comparable to skin testing in many instances, both the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology recognize that allergen-specific serum IgE testing may be preferred in some clinical situations. These include (1) the presence of widespread skin disease, (2) the recent use of antihistamines or other medications that can affect the results of allergy skin tests, (3) uncooperative patients, and (4) medical history suggesting that allergen skin testing would pose a significant risk for a serious allergic reaction [2]. A definitive clinical diagnosis of allergy should not be based on the results of any single diagnostic method but should be made by a trained healthcare provider after all clinical and laboratory findings have been evaluated. More specific information about this allergen can be found on the following web page: https://www.thermofisher.com/diagnostic-education/hcp/us/en/resource-center/allergen-encyclopedia/whole-allergens.html?key=k79 References
1. Venables KM. Br J Ind Med. 1989 Apr;46(4):222-32.
2. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3)S1-S148.
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Allergy blood testing,
Price:
$80
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pH, Urine, Novus
*Build Your Own Panel Eligible [?]
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$49
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Description:
Certain dietary conditions can produce acid or alkaline urines, which can be useful in treatment of some calculi.
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Price:
$49
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Phytohemagglutinin (PHA)-induced Lymphocyte Proliferation
*Build Your Own Panel Eligible [?]
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$394
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Description:
Measurement of human lymphocytes' proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. Mitogens, such as plant lectins phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), are able to nonspecifically stimulate lymphocyte proliferation and used to evaluate patient immune responsiveness.
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Price:
$394
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Pigeon Feathers (e215) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against pigeon feathers. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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PIK3CA Mutation Analysis
*Build Your Own Panel Eligible [?]
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$500
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Description:
Phosphoinositide 3-kinase (PI3K) is a lipid kinase responsible for the generation of an important signaling second messenger involved in cell survival and proliferation. The most highly expressed catalytic subunit, p110alpha, is encoded by the PIK3CA gene (Ch3q26.32). PIK3CA has been shown to be mutated in a high percentage of human cancer (10-15% overall), including endometrial (36%), breast (27%), and colorectal cancers (23%).Mutational hotspots in PIK3CA include exons 1, 9 and 20. Mutations in these regions have been reported to be associated with poor outcome in each of these malignancies and may provide patient stratification in breast cancers. In addition, mutations in PIK3CA correlate with resistance to cetuximab therapy in colorectal cancer patients. PIK3CA mutation status may therefore provide prognostic information for a number of solid tumors, as well as aid in the improvement of molecular stratification of patients.PIK3CA mutation status, especially in combination with other molecular tests, will also be an important consideration in the design of therapeutic strategies for certain malignancies. This test covers greater than 95% of the reported mutations in PIK3CA.
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Price:
$500
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Pineapple (f210) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against pineapple. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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Pine Nut (f253) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test detects the presence of specific IgE against pine nuts. A positive test only indicates that a person is sensitized and potentially allergic to this allergen. A diagnosis of allergy requires clinical signs and symptoms that appear to be associated with exposure to the allergen in addition to the detection of markers of IgE sensitization [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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Pine (t213) IgE
*Build Your Own Panel Eligible [?]
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$49
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Description:
This test quantifies an individual's IgE response to pine. Allergen-specific serum IgE testing is considered comparable to skin testing and may be preferred in some clinical situations. However, a positive test result only indicates that a patient is sensitized to the allergen of concern. Many IgE-sensitized individuals do not develop any symptoms when exposed to the allergen. A diagnosis of allergy should only be made by a trained medical provider after conducting a thorough clinical evaluation [1].More specific information about this allergen can be found on the following website: https://www.thermofisher.com/phadia/us/en/resources/allergen-encyclopedia.htmlReference1. Bernstein IL, et al. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
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Price:
$49
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